Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.2 extracted from

  • Guo, F.; Zhao, S.; Li, X.
    Discovery of novel pyruvate dehydrogenase kinases inhibitors by screening of an in-house small molecule library for anti-lung cancer therapeutics (2019), Bioorg. Med. Chem. Lett., 29, 291-296 .
    View publication on PubMed
Search for more literature for 2.7.11.2

Inhibitors

Inhibitors Comment Organism Structure
2-[5-[(2S)-1-benzylpiperidin-2-yl]-3-(oxan-4-yl)-1H-1,2,4-triazol-1-yl]ethan-1-ol 93.7% inhibition at 0.01 mM Homo sapiens
4-[[(3S)-3-(2-hydroxyethyl)-4-(3-methylbut-2-en-1-yl)piperazin-1-yl]methyl]-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one 86.4% inhibition at 0.01 mM Homo sapiens
5-[(1,3-benzodioxol-5-yloxy)methyl]-N-(imidazo[1,2-a]pyridin-3-ylmethyl)-N-methyl-1H-pyrazole-3-carboxamide 95.6% inhibition at 0.01 mM Homo sapiens
Dichloroacetate
-
 Homo sapiens
dichloroacetophenone
-
 Homo sapiens
N-butyl-3-(2-hydroxyphenyl)-N-(pyridin-4-ylmethyl)-1H-pyrazole-5-carboxamide 89.6% inhibition at 0.01 mM Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + pyruvate dehydrogenase complex Homo sapiens
-
 ADP + phosphorylated pyruvate dehydrogenase complex
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q15118
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MRC-5 cell
-
 Homo sapiens
-
NCI-H1975 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + pyruvate dehydrogenase complex
-
 Homo sapiens ADP + phosphorylated pyruvate dehydrogenase complex
-
 ?

Synonyms

Synonyms Comment Organism
PDK1
-
 Homo sapiens
pyruvate dehydrogenase kinase 1
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0059
-
 enzyme from A-549 cells, pH and temperature not specified in the publication Homo sapiens 2-[5-[(2S)-1-benzylpiperidin-2-yl]-3-(oxan-4-yl)-1H-1,2,4-triazol-1-yl]ethan-1-ol
0.0076
-
 enzyme from NCI-H1650 cells, pH and temperature not specified in the publication Homo sapiens 2-[5-[(2S)-1-benzylpiperidin-2-yl]-3-(oxan-4-yl)-1H-1,2,4-triazol-1-yl]ethan-1-ol
0.0157
-
 enzyme from NCI-H1650 cells, pH and temperature not specified in the publication Homo sapiens 5-[(1,3-benzodioxol-5-yloxy)methyl]-N-(imidazo[1,2-a]pyridin-3-ylmethyl)-N-methyl-1H-pyrazole-3-carboxamide
0.0178
-
 enzyme from A-549 cells, pH and temperature not specified in the publication Homo sapiens 5-[(1,3-benzodioxol-5-yloxy)methyl]-N-(imidazo[1,2-a]pyridin-3-ylmethyl)-N-methyl-1H-pyrazole-3-carboxamide