Literature summary for 2.7.11.2 extracted from

Attia, R.R.; Sharma, P.; Janssen, R.C.; Friedman, J.E.; Deng, X.; Lee, J.S.; Elam, M.B.; Cook, G.A.; Park, E.A.
Regulation of pyruvate dehydrogenase kinase 4 (PDK4) by CCAAT/enhancer-binding protein beta (C/EBPbeta) (2011), J. Biol. Chem., 286, 23799-23807.

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Protein Variants

Protein Variants	Comment	Organism
additional information	knockdown of C/EBPbeta with siRNA	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brown adipose tissue	-	Rattus norvegicus	-
hepatocyte	primary	Rattus norvegicus	-
kidney	-	Rattus norvegicus	-
liver	-	Rattus norvegicus	-

Synonyms

Synonyms	Comment	Organism
PDK4	-	Rattus norvegicus
pyruvate dehydrogenase kinase 4	-	Rattus norvegicus

Expression

Organism	Comment	Expression
Rattus norvegicus	Pdk4 gene expression is inhibited by insulin. Knockdown of C/EBPbeta reduces Pdk4 gene expression and decreases the T3 induction of PDK4 in primary hepatocytes	down
Rattus norvegicus	C/EBPbeta induces Pdk4 gene expression and increases PDK4 promoter activity, and decreases pyruvate dehydrogenase complex activity. Binding of C/EBPbeta via its sequence elements localized between -634 to -626 and -96 to -87. Pdk4 is also induced by thyroid hormone T3, glucocorticoids, retinoic acid, and long chain fatty acids. The peroxisome proliferator-activated receptor gamma coactivator PGC-1alpha enhances the T3 induction of the Pdk4 expression	up

General Information

General Information	Comment	Organism
physiological function	regulation of Pdk4 gene expression by the CCAAT/enhancer-binding protein beta, i.e. C/EBPbeta, which modulates the expression of multiple hepatic genes including those involved in metabolism, development, and inflammation. C/EBPbeta induces Pdk4 gene expression and decreases pyruvate dehydrogenase complex activity, and it participates in the T3 induction of the Cpt1a and Pdk4 genes, overview	Rattus norvegicus

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Release 2023.1 (January 2023)