Literature summary for 2.7.11.2 extracted from

Herbst, E.A.; Dunford, E.C.; Harris, R.A.; Vandenboom, R.; Leblanc, P.J.; Roy, B.D.; Jeoung, N.H.; Peters, S.J.
Role of pyruvate dehydrogenase kinase 4 in regulating PDH activation during acute muscle contraction (2012), Appl. Physiol. Nutr. Metab., 37, 48-52.

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
skeletal muscle	extensor digitorum muscle	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
PDK4	-	Mus musculus
pyruvate dehydrogenase kinase 4	-	Mus musculus

General Information

General Information	Comment	Organism
malfunction	pyruvate dehydrogenase activity is 2.5fold higher at rest in PDK4 knockout mouse muscle compared to the wild-type, and about 2fold in activated muscle at low and high intensity contraction	Mus musculus
physiological function	pyruvate dehydrogenase kinase 4 is one of four PDH kinases regulating the function of the pyruvate dehydrogenase complex, PDH. PDK4 is responsible for reducing PDH activity during low- to moderate-intensity muscle stimulation for contraction of the extensor digitorum muscle	Mus musculus

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Release 2023.1 (January 2023)