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Literature summary for 2.7.11.2 extracted from

  • Zhang, Y.; Ma, K.; Sadana, P.; Chowdhury, F.; Gaillard, S.; Wang, F.; McDonnell, D.P.; Unterman, T.G.; Elam, M.B.; Park, E.A.
    Estrogen-related receptors stimulate pyruvate dehydrogenase kinase isoform 4 gene expression (2006), J. Biol. Chem., 281, 39897-39906.
    View publication on PubMed
Search for more literature for 2.7.11.2

Activating Compound

Activating Compound Comment Organism Structure
additional information the peroxisome proliferator-activated receptor gamma coactivator, PGC-1gamma, as well as estrogen-related receptors ERRalpha and ERRgamma stimulate the expression of isozymes PDK2 and PDK4, the latter being inhibited by insulin, expression of the PDK genes is elevated in diabetes, leading to the decreased oxidation of pyruvate to acetyl-CoA, overview Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression of isozyme PDK4-luciferase in McA-RH7777 cells using the adenovirus transfection method, PDK2 and PDK4 expression analysis, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Insulin decreases the expression of the PDK4 gene, inhibits the induction of PDK4 by ERRalpha and ERRgamma Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens phosphorylation of the pyruvate dehydrogenase complex PDC by the pyruvate dehydrogenase kinases PDK2 and PDK4 inhibits PDC activity, expression of the PDK genes is elevated in diabetes, leading to the decreased oxidation of pyruvate to acetyl-CoA, transcriptional regulation of the PDK4 gene by the estrogen-related receptors ERRalpha and ERRgamma, the ERRs are orphan nuclear receptors whose physiological roles include the induction of fatty acid oxidation in heart and muscle, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Homo sapiens
-
hepatoma cell
-
 Homo sapiens
-
skeletal muscle
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information phosphorylation of the pyruvate dehydrogenase complex PDC by the pyruvate dehydrogenase kinases PDK2 and PDK4 inhibits PDC activity, expression of the PDK genes is elevated in diabetes, leading to the decreased oxidation of pyruvate to acetyl-CoA, transcriptional regulation of the PDK4 gene by the estrogen-related receptors ERRalpha and ERRgamma, the ERRs are orphan nuclear receptors whose physiological roles include the induction of fatty acid oxidation in heart and muscle, overview Homo sapiens ?
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 ?

Synonyms

Synonyms Comment Organism
PDK
-
 Homo sapiens
pyruvate dehydrogenase kinase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens