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Literature summary for 2.7.11.2 extracted from
- YIL042c and YOR090c encode the kinase and phosphatase of the Saccharomyces cerevisiae pyruvate dehydrogenase complex (2006), FEBS Lett., 580, 2553-2560.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene YIL042c, overexpression of c-Myc-tagged or HA-tagged enzyme in strain BY4741 | Saccharomyces cerevisiae |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Saccharomyces cerevisiae | 5739 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + Pda1p subunit | Saccharomyces cerevisiae | the enzyme is the kinase of the Saccharomyces cerevisiae pyruvate dehydrogenase complex, which negatively regulates the complex by reversible phosphorylation of its Pda1p subunit, overview | ADP + phosphorylated Pda1p subunit | - |
? |  |
| ATP + Pda1p subunit | Saccharomyces cerevisiae BY4741 | the enzyme is the kinase of the Saccharomyces cerevisiae pyruvate dehydrogenase complex, which negatively regulates the complex by reversible phosphorylation of its Pda1p subunit, overview | ADP + phosphorylated Pda1p subunit | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
gene YIL042c | - |
| Saccharomyces cerevisiae BY4741 | - |
gene YIL042c | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| recombinant c-Myc-tagged or HA-tagged enzyme from strain BY4741 mitochondria by tandem affinity chromatography | Saccharomyces cerevisiae |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
pyruvate dehydrogenase complex activities of wild-type and recombinant strains | Saccharomyces cerevisiae |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + Pda1p subunit | the enzyme is the kinase of the Saccharomyces cerevisiae pyruvate dehydrogenase complex, which negatively regulates the complex by reversible phosphorylation of its Pda1p subunit, overview | Saccharomyces cerevisiae | ADP + phosphorylated Pda1p subunit | - |
? | |
| ATP + Pda1p subunit | the enzyme is the kinase of the Saccharomyces cerevisiae pyruvate dehydrogenase complex, which negatively regulates the complex by reversible phosphorylation of its Pda1p subunit, overview | Saccharomyces cerevisiae BY4741 | ADP + phosphorylated Pda1p subunit | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | the molecular organization of PDH is influenced by Yil042cp, encoding the enzyme, which is the kinase of the Saccharomyces cerevisiae pyruvate dehydrogenase complex, epitope tagging, overview | Saccharomyces cerevisiae |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Saccharomyces cerevisiae | |
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Release 2023.1 (January 2023)
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