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Literature summary for 2.7.11.2 extracted from

  • Rahmatullah, M.; Roche, T.E.
    Modification of bovine kidney pyruvate dehydrogenase kinase activity by CoA esters and their mechanism of action (1985), J. Biol. Chem., 260, 10146-10152.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
2-oxoisopentanoate
-
Bos taurus
acetoacetyl-CoA slight activation Bos taurus
acetyl-CoA synergism with NADH Bos taurus
benzoyl-CoA slight activation Bos taurus
L-methylmalonyl-CoA slight activation Bos taurus
malonyl-CoA
-
Bos taurus
NADH activation, in the presence of K+ Bos taurus
propionyl-CoA slight activation at low concentrations, synergism with NADH plus NAD+ Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
butyryl-CoA at high concentrations Bos taurus
decanoyl-CoA
-
Bos taurus
hexanoyl-CoA
-
Bos taurus
linolenoyl-CoA
-
Bos taurus
linoleoyl-CoA
-
Bos taurus
additional information no inhibition by succinyl-CoA, tiglyl-CoA, crotonyl-CoA, glutaryl-CoA, DL-3-hydroxy-3-methylglutaryl-CoA, acetylcarnitine or 3-hydroxybutyryl-CoA Bos taurus
myristoyl-CoA
-
Bos taurus
oleoyl-CoA
-
Bos taurus
stearoyl-CoA
-
Bos taurus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ requirement Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [pyruvate dehydrogenase (lipoamide)] Bos taurus catalyzes inactivation through phosphorylation of pyruvate dehydrogenase complex EC 1.2.4.1 ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
ir

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [pyruvate dehydrogenase (lipoamide)]
-
Bos taurus ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
ir
ATP + [pyruvate dehydrogenase (lipoamide)] catalyzes inactivation through phosphorylation of pyruvate dehydrogenase complex EC 1.2.4.1 Bos taurus ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
ir

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.3
-
assay at Bos taurus

Cofactor

Cofactor Comment Organism Structure
ATP dependent on Bos taurus
additional information no activation by succinyl-CoA, tiglyl-CoA, crotonyl-CoA, glutaryl-CoA, DL-3-hydroxy-3-methylglutaryl-CoA, acetylcarnitine or 3-hydroxybutyryl-CoA Bos taurus