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Literature summary for 2.7.11.2 extracted from

  • Roche, T.E.; Reed, L.J.
    Monovalent cation requirement for ADP inhibition of pyruvate dehydrogenase kinase (1974), Biochem. Biophys. Res. Commun., 59, 1341-1348.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
ADP competitive to ATP; inhibition only in the presence of monovalent cations; Mg2+ does not protect Bos taurus
ATP above 0.5 mM, substrate inhibition, only in the presence of K+, Mg2+ does not protect Bos taurus
K+ synergism with ADP Bos taurus
Na+ above 50 mM, alone and synergism with ADP Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information the Km value for ADP depends on the presence and concentration of K+, effect of K+ on kinetic parameters Bos taurus

Metals/Ions

Metals/Ions Comment Organism Structure
K+ inhibits in presence of ADP Bos taurus
Mg2+ requirement Bos taurus
Mg2+ actual substrate: MgATP2- Bos taurus
NH4+ activation in the absence of ADP, inhibits in presence of ADP Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [pyruvate dehydrogenase (lipoamide)] Bos taurus catalyzes inactivation through phosphorylation of pyruvate dehydrogenase complex EC 1.2.4.1 ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
ir

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [pyruvate dehydrogenase (lipoamide)]
-
Bos taurus ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
ir
ATP + [pyruvate dehydrogenase (lipoamide)] catalyzes inactivation through phosphorylation of pyruvate dehydrogenase complex EC 1.2.4.1 Bos taurus ADP + [pyruvate dehydrogenase (lipoamide)] phosphate
-
ir

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Bos taurus

Cofactor

Cofactor Comment Organism Structure
ATP dependent on Bos taurus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information Ki value for ADP depends on the presence and concentration of monovalent cations, e.g. NH4+ or K+ Bos taurus