Activating Compound | Comment | Organism | Structure |
---|---|---|---|
dihydrolipoyl transacetylase | - |
Bos taurus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-oxobutyrate | - |
Bos taurus | |
ADP | competitive to ATP | Bos taurus | |
CaCl2 | no inhibition | Bos taurus | |
additional information | no inhibition by 2-oxoglutarate; no inhibition by cAMP | Bos taurus | |
pyruvate | synergism with ADP | Bos taurus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0006 | - |
[pyruvate dehydrogenase (acetyl-transferring)] | pH 7.5, 30°C | Bos taurus | |
0.0006 | - |
[pyruvate dehydrogenase (acetyl-transferring)] | in presence of dihydrolipoyl transacetylase | Bos taurus | |
0.02 | - |
ATP | kidney enzyme | Bos taurus | |
0.02 | - |
Mg2+ | kidney enzyme | Bos taurus | |
0.02 | - |
ATP | pH 7.5, 30°C | Bos taurus | |
0.02 | - |
Mg2+ | pH 7.5, 30°C | Bos taurus | |
0.02 | - |
[pyruvate dehydrogenase (acetyl-transferring)] | pH 7.5, 30°C | Bos taurus | |
0.02 | - |
[pyruvate dehydrogenase (acetyl-transferring)] | in absence of dihydrolipoyl transacetylase | Bos taurus | |
0.02 | - |
ATP | pyruvate dehydrogenase complex | Bos taurus | |
0.02 | - |
Mg2+ | pyruvate dehydrogenase complex | Bos taurus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Bos taurus | 5739 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | requirement | Bos taurus | |
Mg2+ | actual substrate: MgATP2- | Bos taurus | |
Mn2+ | requirement | Bos taurus | |
Mn2+ | can replace Mg2+ to some extent | Bos taurus | |
additional information | no activation by Ca2+ | Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + [pyruvate dehydrogenase (lipoamide)] | Bos taurus | regulatory role | ADP + [pyruvate dehydrogenase (lipoamide)] phosphate | - |
ir | |
ATP + [pyruvate dehydrogenase (lipoamide)] | Bos taurus | catalyzes inactivation through phosphorylation of pyruvate dehydrogenase complex EC 1.2.4.1 | ADP + [pyruvate dehydrogenase (lipoamide)] phosphate | - |
ir |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Bos taurus | - |
kidney | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + casein | kidney enzyme, low activity | Bos taurus | ADP + casein phosphate | - |
? | |
ATP + [pyruvate dehydrogenase (acetyl-transferring)] | - |
Bos taurus | ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate | - |
? | |
ATP + [pyruvate dehydrogenase (lipoamide)] | - |
Bos taurus | ADP + [pyruvate dehydrogenase (lipoamide)] phosphate | - |
ir | |
ATP + [pyruvate dehydrogenase (lipoamide)] | regulatory role | Bos taurus | ADP + [pyruvate dehydrogenase (lipoamide)] phosphate | - |
ir | |
ATP + [pyruvate dehydrogenase (lipoamide)] | catalyzes inactivation through phosphorylation of pyruvate dehydrogenase complex EC 1.2.4.1 | Bos taurus | ADP + [pyruvate dehydrogenase (lipoamide)] phosphate | - |
ir | |
additional information | no activity with histones of calf thymus type II-A | Bos taurus | ? | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Bos taurus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | 7.2 | in presence of Mg2+ or Mn2+ | Bos taurus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
5.5 | 8.5 | about 50% or 60% of maximal activity at pH 5.5 and about 65% or 50% of maximal activity at pH 8.5, in the presence of Mg2+ or Mn2+, respectively | Bos taurus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | dependent on | Bos taurus | |
additional information | no activation by cAMP | Bos taurus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.1 | - |
ADP | pH 7.5, 30°C | Bos taurus |