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Literature summary for 2.7.11.19 extracted from

  • Chebotareva, N.A.; Meremyanin, A.V.; Makeeva, V.F.; Livanova, N.B.; Kurganov, B.I.
    Cooperative self-association of phosphorylase kinase from rabbit skeletal muscle (2008), Biophys. Chem., 133, 45-53.
    View publication on PubMed
Search for more literature for 2.7.11.19

Activating Compound

Activating Compound Comment Organism Structure
additional information trimethylamin N-oxide induces association Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
EGTA addition of EGTA reverses Ca2+ induced association Oryctolagus cuniculus
NaCl 100 mM NaCl suppresses effect of Ca2+ and Mg2+ Oryctolagus cuniculus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ induces association, obligatory allosteric activator, binds to an integral, nondissociable molecule of calmodulin (delta-subunit), and thus reveals the protein kinase activity of the catalytic gamma-subunit, which in the absence of Ca2+ ions is constrained by the regulatory alpha- and beta-subunits Oryctolagus cuniculus
Mg2+ induces association Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glycogen phosphorylase b + ATP Oryctolagus cuniculus catalyzes phosphorylation and activation of glycogen phosphorylase b and hence plays a key role in the cascade system of regulation of glycogen metabolism glycogen phosphorylase a + ADP
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 ?

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
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-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
skeletal muscle
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 Oryctolagus cuniculus
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Storage Stability

Storage Stability Organism
20 °C, 25 mM Na-glycerol phosphate buffer, pH 7.05, 1 mM EDTA, 0.5 mM 2-mercaptoetanol, 50% glycerol, stored for 3 weeks Oryctolagus cuniculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glycogen phosphorylase b + ATP catalyzes phosphorylation and activation of glycogen phosphorylase b and hence plays a key role in the cascade system of regulation of glycogen metabolism Oryctolagus cuniculus glycogen phosphorylase a + ADP
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 ?

Subunits

Subunits Comment Organism
hexadecamer 4 * alpha + 4 * beta + 4 * gamma + 4 * delta Oryctolagus cuniculus

Synonyms

Synonyms Comment Organism
EC 2.7.1.38 formerly, transferred to EC 2.7.11.19 Oryctolagus cuniculus
PhK
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 Oryctolagus cuniculus

Cofactor

Cofactor Comment Organism Structure
additional information capable of binding FAD, binding of FAD suppresses self association of enzyme Oryctolagus cuniculus