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Literature summary for 2.7.11.19 extracted from

  • Picton, C.; Shenolikar, S.; Grand, R.; Cohen, P.
    Calmodulin as an integral subunit of phosphorylase kinase from rabbit skeletal muscle (1983), Methods Enzymol., 102, 219-227.
    View publication on PubMed
Search for more literature for 2.7.11.19

Activating Compound

Activating Compound Comment Organism Structure
Troponin i.e. complex of troponin C, I and T, activation, as effective as troponin C, forms complex with beta subunit Oryctolagus cuniculus
troponin C activation Oryctolagus cuniculus
troponin C can replace extrinsic calmodulin Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
Calcineurin i.e. calmodulin-binding protein, blocks activation by calmodulin Oryctolagus cuniculus
Trifluoperazine prevents activation by troponin C Oryctolagus cuniculus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
 Oryctolagus cuniculus
Mg2+ requirement Oryctolagus cuniculus
Mg2+ major role of Mg2+: cosubstrate in Mg2+-ATP complex Oryctolagus cuniculus
phosphate requirement, phosphate containing enzyme Oryctolagus cuniculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
17000
-
 4 * 145000 + 4 * 130000 + 4 * 45000 + 4 * 17000, (alphabetagammadelta)4, rabbit, SDS-PAGE Oryctolagus cuniculus
45000
-
 4 * 145000 + 4 * 130000 + 4 * 45000 + 4 * 17000, (alphabetagammadelta)4, rabbit, SDS-PAGE Oryctolagus cuniculus
130000
-
 4 * 145000 + 4 * 130000 + 4 * 45000 + 4 * 17000, (alphabetagammadelta)4, rabbit, SDS-PAGE Oryctolagus cuniculus
145000
-
 4 * 145000 + 4 * 130000 + 4 * 45000 + 4 * 17000, (alphabetagammadelta)4, rabbit, SDS-PAGE Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + glycogen phosphorylase Oryctolagus cuniculus conversion to an AMP-independent form, key enzyme of neural and hormonal control of glycogen metabolism ?
-
 ?
ATP + glycogen synthase Oryctolagus cuniculus key enzyme of neural and hormonal control of glycogen metabolism ?
-
 ?
ATP + glycogen synthase Oryctolagus cuniculus conversion to a glucose 6-phosphate dependent form ?
-
 ?
ATP + phosphorylase b Oryctolagus cuniculus i.e. EC 2.4.1.1 or glycogen phosphorylase ?
-
 ?
ATP + phosphorylase b Oryctolagus cuniculus key enzyme of neural and hormonal control of glycogen metabolism ?
-
 ?

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
skeletal muscle
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + glycogen phosphorylase conversion to an AMP-independent form, key enzyme of neural and hormonal control of glycogen metabolism Oryctolagus cuniculus ?
-
 ?
ATP + glycogen synthase key enzyme of neural and hormonal control of glycogen metabolism Oryctolagus cuniculus ?
-
 ?
ATP + glycogen synthase conversion to a glucose 6-phosphate dependent form Oryctolagus cuniculus ?
-
 ?
ATP + glycogen synthase phosphorylatable residue: Ser-7 Oryctolagus cuniculus ADP + phosphoglycogen synthase
-
 ?
ATP + phosphorylase b i.e. EC 2.4.1.1 or glycogen phosphorylase Oryctolagus cuniculus ADP + phosphorylase a
-
 ?
ATP + phosphorylase b cosubstrate: Mg-ATP complex Oryctolagus cuniculus ADP + phosphorylase a
-
 ?
ATP + phosphorylase b phosphorylation site located 14 residues from amino terminal Oryctolagus cuniculus ADP + phosphorylase a
-
 ?
ATP + phosphorylase b i.e. EC 2.4.1.1 or glycogen phosphorylase Oryctolagus cuniculus ?
-
 ?
ATP + phosphorylase b key enzyme of neural and hormonal control of glycogen metabolism Oryctolagus cuniculus ?
-
 ?

Subunits

Subunits Comment Organism
hexadecamer 4 * 145000 + 4 * 130000 + 4 * 45000 + 4 * 17000, (alphabetagammadelta)4, rabbit, SDS-PAGE Oryctolagus cuniculus

Cofactor

Cofactor Comment Organism Structure
Calmodulin requirement Oryctolagus cuniculus
Calmodulin calmodulin containing enzyme i.e. tightly bound delta subunit Oryctolagus cuniculus
Calmodulin calmodulin containing enzyme in the absence of Ca2+ Oryctolagus cuniculus
Calmodulin tightly bound molecule interacts with additional calmodulin in the presence of Ca2+ Oryctolagus cuniculus