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Literature summary for 2.7.11.19 extracted from

  • Kilimann, M.W.; Heilmeyer, L.M.G.
    Multiple activities on phosphorylase kinase. 2. Different specificities toward the protein substrates phosphorylase b, troponin, and phosphorylase kinase (1982), Biochemistry, 21, 1735-1739.
    View publication on PubMed
Search for more literature for 2.7.11.19

Activating Compound

Activating Compound Comment Organism Structure
Catalytic subunit of cAMP-dependent protein kinase activation of nonactivated enzyme Oryctolagus cuniculus
additional information autophosphorylation Oryctolagus cuniculus
additional information the nonactivated enzyme is activated either by limited proteolysis Oryctolagus cuniculus
additional information three separate activities can be characterized by their response to Ca2+, Mg2+, NH4Cl and pH: A0, A1 and A2 Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
NH4Cl
-
 Oryctolagus cuniculus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ Ca2+-independent activity: A0 Oryctolagus cuniculus
Ca2+ stimulates autophosphorylation in micromolar range at pH 6.8, inhibits at millimolar range Oryctolagus cuniculus
Ca2+ required for activity and activation Oryctolagus cuniculus
Mg2+ requirement Oryctolagus cuniculus
Mg2+ major role of Mg2+: cosubstrate in Mg2+-ATP complex Oryctolagus cuniculus
additional information three separate activities can be characterized by their response to Ca2+, Mg2+, NH4Cl and pH: A0, A1 and A2 Oryctolagus cuniculus
phosphate requirement, phosphate containing enzyme Oryctolagus cuniculus

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + nonactivated phosphorylase kinase i.e. autophosphorylation and autoactivation Oryctolagus cuniculus ADP + activated phosphorylase kinase
-
 ?
ATP + phosphorylase b cosubstrate: Mg-ATP complex Oryctolagus cuniculus ADP + phosphorylase a
-
 ?
ATP + troponin I
-
 Oryctolagus cuniculus ADP + phosphotroponin I
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Oryctolagus cuniculus