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Literature summary for 2.7.11.19 extracted from

  • Adams, J.A.
    Kinetic and catalytic mechanisms of protein kinases (2001), Chem. Rev., 101, 2271-2290.
    View publication on PubMed
Search for more literature for 2.7.11.19

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information random kinetic mechanism, reaction order can be influenced by the sort of substrate eukaryota

Metals/Ions

Metals/Ions Comment Organism Structure
Cd2+ can partially substitue Mg2+ eukaryota
Co2+ can partially substitue Mg2+ eukaryota
Mg2+ dependent on, Mg2+ is the physiologic metal ion, other divalent cations are able to support nucleotide binding, but only Mn2+, Co2+, and Cd2+ can substitute Mg2+ in supporting the catalytic activity eukaryota
Mn2+ can partially substitue Mg2+ eukaryota

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + phosphorylase b eukaryota
-
 ADP + phosphorylase a
-
 ?

Organism

Organism UniProt Comment Textmining
eukaryota
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a protein
-
 eukaryota ADP + a phosphoprotein
-
 ?
ATP + phosphorylase b
-
 eukaryota ADP + phosphorylase a
-
 ?
additional information poor activity on free amino acids, consensus sequence of PhK is R-XXS/TF-F eukaryota ?
-
 ?

Subunits

Subunits Comment Organism
More phosphorylase kinase is a multisubunit protein kinase with molecular weight above 1000000 Da eukaryota

Synonyms

Synonyms Comment Organism
PhK
-
 eukaryota

Cofactor

Cofactor Comment Organism Structure
ATP dependent on eukaryota