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Literature summary for 2.7.11.18 extracted from
- MLC-kinase/phosphatase control of Ca2+ signal transduction in airway smooth muscles (2008), J. Theor. Biol., 252, 474-481.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Calmodulin | required | Rattus norvegicus |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | Michaelis-Menten kinetics, kinetic scheme of the mathematical model considers interactions among Ca2+, calmodulin and MLCK, and the well-known 4-state actomyosin latch bridge model, whereby a link between them is accomplished by the conservation relation of all species of MLCK, detailed overview | Rattus norvegicus |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | required | Rattus norvegicus | |
| Mg2+ | - |
Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + myosin light chain | Rattus norvegicus | in airway smooth muscles, kinase/phosphatase-dependent phosphorylation and dephosphorylation of the myosin light chain is an important step in calcium signalling pathway from the variation of Ca2+ concentration in cytosol to the force development | ADP + myosin light chain phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| lung | - |
Rattus norvegicus | - |
| smooth muscle | airway | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + myosin light chain | - |
Rattus norvegicus | ADP + myosin light chain phosphate | - |
? | |
| ATP + myosin light chain | in airway smooth muscles, kinase/phosphatase-dependent phosphorylation and dephosphorylation of the myosin light chain is an important step in calcium signalling pathway from the variation of Ca2+ concentration in cytosol to the force development | Rattus norvegicus | ADP + myosin light chain phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MLC-kinase | - |
Rattus norvegicus |
| MLCK | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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