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Literature summary for 2.7.11.18 extracted from
- Maximal stimulation-induced in situ myosin light chain kinase activity is upregulated in fetal compared to adult ovine carotid arteries (2008), Am. J. Physiol. Heart Circ. Physiol., 295, H2289-H2298.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Calmodulin | - |
Ovis aries |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ML-7 | specific inhibitor for MLCK | Ovis aries | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Ovis aries | 5829 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | - |
Ovis aries | |
| Mg2+ | - |
Ovis aries | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + myosin light chain | Ovis aries | MLCK plays a critically important role in regulation of contraction in both smooth muscle and non-muscle cells, MLCK is both necessary and sufficient to initiate smooth muscle contraction | ADP + myosin light chain phosphate | - |
? | |
| additional information | Ovis aries | postnatal decreases in vascular reactivity involve decreases in the thick filament component of myofilament calcium sensitivity, which is measured as the relationship between cytosolic calcium concentration and myosin light chain phosphorylation, relations between myosin light chain phosphorylation and contractile force, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Ovis aries | O02827 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| artery | maximal stimulation-induced in situ myosin light chain kinase activity is upregulated in fetal compared to adult ovine carotid arteries | Ovis aries | - |
| carotid atherosclerotic plaque | fetal and adult, quantification of the enzyme and its product | Ovis aries | - |
| smooth muscle cell | - |
Ovis aries | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
quantitative determination of phosphorylated myosin light chain | Ovis aries |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + myosin light chain | - |
Ovis aries | ADP + myosin light chain phosphate | - |
? | |
| ATP + myosin light chain | MLCK plays a critically important role in regulation of contraction in both smooth muscle and non-muscle cells, MLCK is both necessary and sufficient to initiate smooth muscle contraction | Ovis aries | ADP + myosin light chain phosphate | - |
? | |
| additional information | postnatal decreases in vascular reactivity involve decreases in the thick filament component of myofilament calcium sensitivity, which is measured as the relationship between cytosolic calcium concentration and myosin light chain phosphorylation, relations between myosin light chain phosphorylation and contractile force, overview | Ovis aries | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MLCK | - |
Ovis aries |
| myosin light chain kinase | - |
Ovis aries |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Ovis aries |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Ovis aries |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Ovis aries | |
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Release 2023.1 (January 2023)
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