Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.18 extracted from

  • Reynoso, R.; Perrin, R.M.; Breslin, J.W.; Daines, D.A.; Watson, K.D.; Watterson, D.M.; Wu, M.H.; Yuan, S.
    A role for long chain myosin light chain kinase (MLCK-210) in microvascular hyperpermeability during severe burns (2007), Shock, 28, 589-595.
    View publication on PubMed
Search for more literature for 2.7.11.18

Activating Compound

Activating Compound Comment Organism Structure
Calmodulin
-
 Mus musculus

Application

Application Comment Organism
medicine long isozyme MLCK-210 is a potential therapeutic target in the treatment of burn edema Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information long isozyme MLCK-210-deficient mice display a significantly improved survival with a greatly attenuated microvascular hyperpermeability response to albumin and fluid Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + light chain myosin II Mus musculus MLCK plays a key role in the control of MLC-phosphorylation status, and it modulates barrier function through its regulation of intracellular contractile machinery, overview, endothelial mechanism of MLC-dependent barrier injury in burns, overview ADP + phosphorylated light chain myosin II
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 male strain C57-black6/SV mice, isozyme MLCK-210
-

Source Tissue

Source Tissue Comment Organism Textmining
vascular endothelial cell the long isoform of MLCK, MLCK-210, is the predominant isoform expressed in vascular endothelial cells Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + light chain myosin II
-
 Mus musculus ADP + phosphorylated light chain myosin II
-
 ?
ATP + light chain myosin II MLCK plays a key role in the control of MLC-phosphorylation status, and it modulates barrier function through its regulation of intracellular contractile machinery, overview, endothelial mechanism of MLC-dependent barrier injury in burns, overview Mus musculus ADP + phosphorylated light chain myosin II
-
 ?

Synonyms

Synonyms Comment Organism
long chain myosin light chain kinase
-
 Mus musculus
MLCK
-
 Mus musculus
MLCK-210
-
 Mus musculus
myosin light chain kinase
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus