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Literature summary for 2.7.11.18 extracted from

  • Nakanishi, S.; Ando, K.; Kawamoto, I.; Matsuda, Y.
    MS-347a, a new inhibitor of myosin light chain kinase from Aspergillus sp. KY52178 (1989), J. Antibiot., 46, 1775-1781.
No PubMed abstract available
Search for more literature for 2.7.11.18

Inhibitors

Inhibitors Comment Organism Structure
MS-347a from Aspergillus sp. KY52178, structurally related to sydowinin B, irreversible, inhibition of calmodulin-dependent and independent activity, IC50: 0.0092 mM Gallus gallus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
 Gallus gallus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + myosin light chain Gallus gallus
-
 ADP + myosin light chain phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + myosin light chain
-
 Gallus gallus ADP + myosin light chain phosphate
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
28
-
 assay at Gallus gallus

Cofactor

Cofactor Comment Organism Structure
Calmodulin requirement Gallus gallus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0092
-
 from Aspergillus sp. KY52178, structurally related to sydowinin B, irreversible, inhibition of calmodulin-dependent and independent activity, IC50: 0.0092 mM Gallus gallus MS-347a