Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.18 extracted from

  • Jinsart, W.; Ternai, B.; Polya, G.M.
    Inhibition of myosin light chain kinase, cAMP-dependent protein kinase, protein kinase C and of plant Ca(2+)-dependent protein kinase by anthraquinones (1992), Biol. Chem. Hoppe-Seyler, 373, 903-910.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1,4-diaminoanthraquinone IC50: 0.018 mM Gallus gallus
alizarin IC50: 0.014 mM Gallus gallus
anthraflavic acid IC50: 0.037 mM Gallus gallus
anthrarufin
-
Gallus gallus
chrysazine IC50: 0.02 mM Gallus gallus
chrysophanic acid
-
Gallus gallus
emodin IC50: 0.008 mM Gallus gallus
mitoxanthrone IC50: 0.002 mM Gallus gallus
purpurin IC50: 0.025 mM Gallus gallus
quinalizarin IC50: 0.053 mM Gallus gallus
quinizarin IC50: 0.026 mM Gallus gallus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
Gallus gallus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + myosin light chain Gallus gallus
-
ADP + myosin light chain phosphate
-
?

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
gizzard rat pancreatic and turkey gizzard enzyme are immunologically related Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + Lys-Lys-Arg-Ala-Ala-Arg-Ala-Thr-Ser-Asn-Val-Phe-Ala
-
Gallus gallus ADP + ?
-
?
ATP + myosin light chain
-
Gallus gallus ADP + myosin light chain phosphate
-
?

Cofactor

Cofactor Comment Organism Structure
Calmodulin requirement Gallus gallus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.002
-
IC50: 0.002 mM Gallus gallus mitoxanthrone
0.008
-
IC50: 0.008 mM Gallus gallus emodin
0.014
-
IC50: 0.014 mM Gallus gallus alizarin
0.018
-
IC50: 0.018 mM Gallus gallus 1,4-diaminoanthraquinone
0.02
-
IC50: 0.02 mM Gallus gallus chrysazine
0.025
-
IC50: 0.025 mM Gallus gallus purpurin
0.026
-
IC50: 0.026 mM Gallus gallus quinizarin
0.037
-
IC50: 0.037 mM Gallus gallus anthraflavic acid
0.053
-
IC50: 0.053 mM Gallus gallus quinalizarin