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Literature summary for 2.7.11.18 extracted from

  • Gallagher, P.J.; Herring, B.P.; Griffin, S.A.; Stull, J.T.
    Molecular characterization of a mammalian smooth muscle myosin light chain kinase [published erratum appears in J Biol Chem 1992 May 5;267(13):9450] (1991), J. Biol. Chem., 266, 23936-23944.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in COS cells Oryctolagus cuniculus
expression in COS-cells Oryctolagus cuniculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.005 0.0095 myosin light chain
-
Gallus gallus
0.005 0.0095 myosin light chain
-
Bos taurus
0.005 0.0095 myosin light chain
-
Oryctolagus cuniculus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
Gallus gallus
Ca2+
-
Rattus norvegicus
Ca2+
-
Bos taurus
Ca2+
-
Oryctolagus cuniculus
Ca2+ Ca2+/calmodulin-dependent Oryctolagus cuniculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
125700
-
calculated from sequence of DNA Oryctolagus cuniculus
136000
-
x * 136000, SDS-PAGE, enzyme from smooth muscle Rattus norvegicus
152000
-
x * 152000, SDS-PAGE, recombinant enzyme Oryctolagus cuniculus
155000
-
x * 155000, SDS-PAGE Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + myosin light chain Oryctolagus cuniculus
-
ADP + phosphorylated myosin light chain
-
?
ATP + myosin light chain Rattus norvegicus
-
ADP + myosin light chain phosphate
-
?
ATP + myosin light chain Gallus gallus event in initiation of smooth-muscle contraction ADP + myosin light chain phosphate
-
?
ATP + myosin light chain Bos taurus event in initiation of smooth-muscle contraction ADP + myosin light chain phosphate
-
?
ATP + myosin light chain Oryctolagus cuniculus event in initiation of smooth-muscle contraction ADP + myosin light chain phosphate
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Gallus gallus
-
-
-
Oryctolagus cuniculus
-
-
-
Oryctolagus cuniculus P29294
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal medulla not rat Gallus gallus
-
adrenal medulla not rat Bos taurus
-
adrenal medulla not rat Oryctolagus cuniculus
-
aorta
-
Bos taurus
-
kidney not rat Gallus gallus
-
kidney not rat Bos taurus
-
kidney not rat Oryctolagus cuniculus
-
liver not rat Gallus gallus
-
liver not rat Bos taurus
-
liver not rat Oryctolagus cuniculus
-
additional information myosin light chain kinases in smooth muscle and non-muscle tissues are the same protein Gallus gallus
-
additional information myosin light chain kinases in smooth muscle and non-muscle tissues are the same protein Rattus norvegicus
-
additional information myosin light chain kinases in smooth muscle and non-muscle tissues are the same protein Bos taurus
-
additional information myosin light chain kinases in smooth muscle and non-muscle tissues are the same protein Oryctolagus cuniculus
-
muscle
-
Oryctolagus cuniculus
-
smooth muscle
-
Rattus norvegicus
-
smooth muscle
-
Bos taurus
-
smooth muscle uterus, trachea, aorta, ileum, gizzard Gallus gallus
-
smooth muscle uterus, trachea, aorta, ileum, gizzard Oryctolagus cuniculus
-
uterus
-
Oryctolagus cuniculus
-
uterus not rat Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + myosin light chain
-
Oryctolagus cuniculus ADP + phosphorylated myosin light chain
-
?
ATP + myosin light chain
-
Rattus norvegicus ADP + myosin light chain phosphate
-
?
ATP + myosin light chain acceptor substrates are myosin light chains of smooth muscle Gallus gallus ADP + myosin light chain phosphate
-
?
ATP + myosin light chain acceptor substrates are myosin light chains of smooth muscle Rattus norvegicus ADP + myosin light chain phosphate
-
?
ATP + myosin light chain acceptor substrates are myosin light chains of smooth muscle Bos taurus ADP + myosin light chain phosphate
-
?
ATP + myosin light chain acceptor substrates are myosin light chains of smooth muscle Oryctolagus cuniculus ADP + myosin light chain phosphate
-
?
ATP + myosin light chain event in initiation of smooth-muscle contraction Gallus gallus ADP + myosin light chain phosphate
-
?
ATP + myosin light chain event in initiation of smooth-muscle contraction Bos taurus ADP + myosin light chain phosphate
-
?
ATP + myosin light chain event in initiation of smooth-muscle contraction Oryctolagus cuniculus ADP + myosin light chain phosphate
-
?

Subunits

Subunits Comment Organism
?
-
Gallus gallus
? x * 136000, SDS-PAGE, enzyme from smooth muscle Rattus norvegicus
? x * 152000, SDS-PAGE, recombinant enzyme Oryctolagus cuniculus
? x * 155000, SDS-PAGE Bos taurus

Synonyms

Synonyms Comment Organism
myosin light chain kinase, smooth muscle
-
Oryctolagus cuniculus

Cofactor

Cofactor Comment Organism Structure
Calmodulin requirement Gallus gallus
Calmodulin requirement Rattus norvegicus
Calmodulin requirement Bos taurus
Calmodulin requirement Oryctolagus cuniculus