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Literature summary for 2.7.11.18 extracted from
- Pseudosubstrate-based peptide inhibitors (1991), Methods Enzymol., 201, 287-304.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | synthesis of peptides behaving as pseudosubstrates, determination of inhibitory potential | eukaryota | |
| SKDRMKKYMARRKWQKTGHAVRAI | autoregulatory pseudosubstrate sequence of smooth muscle enzyme, residues 787-810 | eukaryota |  |
| SQRLLKKYLMKRRWKKNFIAVSAA | autoregulatory pseudosubstrate sequence of the skeletal muscle enzyme, residues 570-593 | eukaryota | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
eukaryota | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + myosin light chain | eukaryota | - |
ADP + phosphorylated myosin light chain | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| eukaryota | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| skeletal muscle | - |
eukaryota | - |
| smooth muscle | - |
eukaryota | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + myosin light chain | - |
eukaryota | ADP + phosphorylated myosin light chain | - |
? | |
| additional information | substrate specificity | eukaryota | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MLCK | - |
eukaryota |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
eukaryota | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | Ki values of the pseudosubstrates in nano- to micromolar range | eukaryota |
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