BRENDA - Reference to 2.7.11.18; Id = 709602

ML-7

selective MLCK inhibitor

Mus musculus

-

brain

-

Mus musculus

-

ATP + myosin light chain

-

709602

Mus musculus

ADP + myosin light chain phosphate

-

?

MLCK

-

Mus musculus

myosin light chain kinase

-

Mus musculus

ATP

-

Mus musculus

ATP

-

Mus musculus

ML-7

selective MLCK inhibitor

Mus musculus

brain

-

Mus musculus

-

ATP + myosin light chain

-

709602

Mus musculus

ADP + myosin light chain phosphate

-

?

Mus musculus

MLCK expression is significantly up-regulated after controlled cortical impact with a maximum 12 h post-injury

up

physiological function

phosphorylation of myosin light chains by myosin light chain kinase activates endothelial contractile elements and results in a rearrangement of the cytoskeleton

Mus musculus

physiological function

phosphorylation of myosin light chains by myosin light chain kinase activates endothelial contractile elements and results in a rearrangement of the cytoskeleton

Mus musculus

MLCK expression is significantly up-regulated after controlled cortical impact with a maximum 12 h post-injury

up

739835

Jin

Myosin light chain kinase medi ...

Sus scrofa, Sus scrofa Yorkshire crossbred

Am. J. Physiol. Cell Physiol.

311

C996-C1004

2016

-

1

-

3

-

3

-

2

-

1

-

3

-

2

-

740266

Alcala

Myosin light chain kinase stea ...

Gallus gallus

Cell Biochem. Funct.

34

469-474

2016

1

-

1

5

-

2

-

2

-

1

-

3

-

8

-

5

1

-

5

1

-

1

-

1

-

1

-

1

-

5

-

2

-

2

-

3

-

8

-

1

-

5

1

-

2

-

5

740887

Li

Myosin light chain kinase faci ...

Rattus norvegicus

J. Neurochem.

138

60-73

2016

1

-

1

-

1

-

1

2

-

1

-

2

-

1

-

2

-

3

1

-

1

-

1

-

1

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1

-

1

-

1

-

1

2

-

1

-

1

-

2

-

1

-

1

-

2

-

740026

Vilitkevich

Phosphorylation regulates inte ...

Gallus gallus

Biochemistry (Moscow)

80

1288-1297

2015

2

-

1

-

1

-

1

-

2

1

-

1

-

1

-

1

-

4

-

1

-

2

-

1

-

1

-

1

-

2

1

-

1

-

1

-

2

-

740131

McGinnis

MAPK3/1 (ERK1/2) and myosin li ...

Mus musculus, Mus musculus CF-1

Biol. Reprod.

92

146

2015

1

-

1

-

3

-

2

-

2

-

1

-

2

-

2

-

1

-

1

-

1

-

1

-

3

-

2

-

1

-

2

-

3

-

740793

Lou

Myosin light chain kinase regu ...

Danio rerio, Danio rerio TL

J. Cell Biol.

209

275-288

2015

-

1

-

1

-

1

-

3

-

2

-

4

-

1

-

1

-

1

-

1

-

2

-

2

-

740823

Hong

Diffusion of myosin light chai ...

Homo sapiens

J. Gen. Physiol.

146

267-280

2015

1

-

1

-

1

-

1

2

-

1

-

2

-

1

-

2

-

5

1

-

1

-

1

-

1

-

1

-

1

-

1

2

-

1

-

1

-

2

-

1

-

1

-

1

-

741240

Shen

Structure-function analysis of ...

Homo sapiens

PLoS ONE

10

e0130515

2015

1

-

1

-

3

-

1

-

1

-

1

-

1

-

1

2

-

1

-

1

-

3

-

1

-

1

-

1

-

1

-

3

-

741247

Taniguchi

New isoform of cardiac myosin ...

Mus musculus, Mus musculus C57BL/6N/C57BL/6J

PLoS ONE

10

e0141130

2015

2

-

1

-

1

-

2

1

2

-

4

-

2

-

4

1

3

-

1

-

2

-

1

-

1

-

2

1

2

-

2

-

4

1

-

2

-

740289

Martinsen

Regulation of calcium channels ...

Rattus norvegicus, Rattus norvegicus Wistar

Channels

8

402-413

2014

1

-

1

-

1

-

1

-

2

-

2

-

4

-

2

-

3

-

1

-

1

-

1

-

1

-

1

-

2

-

4

-

2

-

2

-

740727

Chen

Myosin light chain kinase (MLC ...

Mus musculus

J. Biol. Chem.

289

28478-28488

2014

1

-

1

-

1

-

2

-

1

-

1

-

2

-

2

1

2

-

1

-

1

-

1

-

1

-

2

-

1

-

2

-

2

1

-

2

-

740060

Hong

Kinetics of myosin light chain ...

Gallus gallus

Biochemistry

52

8489-8500

2013

3

-

1

-

1

-

2

-

1

-

1

-

2

-

3

-

1

-

1

-

1

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3

-

1

-

1

-

1

-

2

-

1

-

2

-

3

-

1

-

1

-

1

-

708840

Suzuki

The nondigestible disaccharide ...

Rattus norvegicus

J. Agric. Food Chem.

58

1927-1932

2010

1

-

1

-

3

-

1

-

1

-

2

-

1

-

1

-

1

-

1

-

1

-

1

-

709148

Zhang

Myosin light chain kinase is n ...

Mus musculus

J. Biol. Chem.

285

5522-5531

2010

-

1

-

2

-

2

-

1

-

2

-

2

-

2

-

1

-

2

-

1

-

2

-

709225

Khuon

Myosin light chain kinase medi ...

Bos taurus

J. Cell Sci.

123

431-440

2010

-

1

-

2

-

1

-

2

-

1

-

1

-

2

-

1

-

1

-

709733

Obara

Interactive role of protein ph ...

Canis lupus familiaris

J. Vasc. Res.

47

115-127

2010

-

1

-

1

-

1

-

2

-

1

-

1

-

1

-

1

-

709858

Brown

Quantitative distribution and ...

Homo sapiens

Microvasc. Res.

80

75-88

2010

-

1

-

2

-

2

-

1

-

3

-

2

-

2

-

1

-

2

-

1

-

707084

Leguillette

Myosin, transgelin, and myosin ...

Homo sapiens

Am. J. Respir. Crit. Care Med.

179

194-204

2009

-

3

-

2

-

1

-

2

-

1

-

1

-

2

-

1

-

1

-

1

-

708142

Takashima

Phosphorylation of myosin regu ...

Rattus norvegicus

Circ. J.

73

208-213

2009

-

1

-

1

-

13

-

2

-

5

-

2

-

2

-

1

-

13

-

2

-

1

-

708823

Xie

Calcium regulation of non-kina ...

Bos taurus, Gallus gallus

IUBMB Life

61

1092-1098

2009

-

2

-

2

-

3

-

2

-

2

-

4

-

4

-

4

-

2

4

-

2

-

2

-

2

-

4

-

709287

Miyauchi

Lactobacillus rhamnosus allevi ...

Homo sapiens, Mus musculus

J. Dairy Sci.

92

2400-2408

2009

-

6

-

2

-

2

-

4

-

2

-

2

-

2

-

2

-

2

-

2

-

709602

Luh

Inhibition of myosin light cha ...

Mus musculus

J. Neurochem.

112

1015-1025

2009

-

1

-

2

-

1

-

1

-

2

-

1

-

1

-

1

-

1

-

1

-

1

-

709692

Raina

Activation by Ca2+/calmodulin ...

Mus musculus

J. Physiol.

587

2599-2612

2009

-

1

2

-

2

-

3

-

1

-

2

-

2

-

2

-

1

2

-

3

-

1

-

709713

Leveille

Androgens down-regulate myosin ...

Homo sapiens

J. Steroid Biochem. Mol. Biol.

114

174-179

2009

-

2

-

8

-

1

-

2

-

1

-

1

-

8

-

1

-

1

-

1

-

709732

Costantini

Pentoxifylline modulates intes ...

Mus musculus

J. Trauma

66

17-24

2009

2

-

3

-

1

-

1

-

2

-

1

-

2

-

1

-

1

-

1

-

1

-

1

-

710379

Shin

Arrest defective-1 controls tu ...

Homo sapiens

PLoS ONE

4

e7451

2009

-

3

-

1

-

3

-

2

-

1

-

2

-

2

-

2

-

3

-

1

-

2

-

1

-

684333

Mizuno

Myosin light chain kinase acti ...

Mus musculus

Am. J. Physiol. Cell Physiol.

295

C358-C364

2008

1

-

2

-

2

-

1

-

2

-

2

1

-

1

-

2

-

1

-

1

-

1

-

2

-

2

-

1

-

2

1

-

1

-

684356

Injeti

Maximal stimulation-induced in ...

Ovis aries

Am. J. Physiol. Heart Circ. Physiol.

295

H2289-H2298

2008

1

-

1

-

1

2

-

2

-

1

-

3

1

-

3

-

2

1

-

1

-

1

-

1

-

1

-

1

-

1

2

-

2

-

3

1

-

3

-

1

-

1

-

684910

Nakamura

Role of non-kinase activity of ...

Bos taurus, Gallus gallus

Biochem. Biophys. Res. Commun.

369

135-143

2008

3

-

2

-

1

-

2

-

4

1

4

-

2

-

2

1

-

6

-

6

2

4

-

2

-

3

-

2

-

1

-

2

-

4

1

4

-

2

1

-

6

-

6

2

-

685933

Zhou

Myosin light-chain kinase cont ...

Homo sapiens

Cancer Lett.

270

312-327

2008

-

2

-

1

-

2

-

1

-

2

-

3

-

2

-

1

-

1

-

2

-

1

-

2

-

2

-

3

-

686119

Chan

Identification of cardiac-spec ...

Mus musculus

Circ. Res.

102

571-580

2008

-

1

-

1

-

1

-

2

-

1

-

4

-

3

-

3

-

1

-

1

-

1

-

1

-

1

-

4

-

3

-

686236

Christie

Variation in the myosin light ...

Homo sapiens

Crit. Care Med.

36

2794-2800

2008

-

1

-

3

-

1

-

2

-

2

-

1

-

2

-

1

-

3

-

1

-

2

-

1

-

686927

He

Myosin light chain kinase is c ...

Mus musculus

Gastroenterology

135

610-620

2008

-

1

-

1

-

1

-

3

-

2

1

-

1

-

2

-

1

-

1

-

1

-

2

1

-

1

-

687732

Horman

AMP-activated protein kinase p ...

Gallus gallus, Mus musculus, Rattus norvegicus

J. Biol. Chem.

283

18505-18512

2008

3

-

1

-

6

-

6

-

6

-

5

-

9

-

6

3

-

3

-

3

-

3

-

3

-

1

-

6

-

6

-

5

-

9

-

3

-

3

-

687922

Borisov

Developmental expression and d ...

Homo sapiens, Mus musculus, Rattus norvegicus

J. Cell. Biochem.

103

1621-1635

2008

3

-

3

-

3

-

3

6

-

6

-

4

-

3

-

15

-

9

-

12

-

3

-

3

-

3

-

3

-

3

6

-

6

-

3

-

15

-

9

-

688218

Chilcoat

Tonic protein kinase A activit ...

Homo sapiens

J. Leukoc. Biol.

83

964-971

2008

-

3

-

1

-

2

-

1

-

1

-

3

-

3

-

1

-

1

-

3

-

1

-

2

-

1

-

3

-

688628

Zhu

Melatonin prevents oxidized lo ...

Homo sapiens

J. Pineal Res.

45

328-334

2008

2

-

2

1

-

2

-

1

-

1

-

3

1

-

1

-

1

-

2

-

1

-

2

1

-

1

-

1

-

1

-

1

-

688705

Fajmut

MLC-kinase/phosphatase control ...

Rattus norvegicus

J. Theor. Biol.

252

474-481

2008

1

-

1

-

2

-

1

-

2

-

2

-

2

-

2

-

1

-

1

-

1

-

1

-

2

-

1

-

2

-

2

-

689353

Feighery

Myosin light chain kinase inhi ...

Homo sapiens, Mus musculus, Mus musculus C57BL/6, Rattus norvegicus

Pharm. Res.

25

1377-1386

2008

3

-

12

-

6

-

5

-

146

-

10

-

5

-

9

-

3

-

1

3

-

3

-

1

12

-

6

-

5

-

10

-

5

-

690160

Moitra

A transgenic mouse with vascul ...

Homo sapiens

Transl. Res.

151

141-153

2008

-

1

-

3

-

1

-

2

-

1

-

1

-

707035

Han

Regulation of myosin light cha ...

Rattus norvegicus

Am. J. Hypertens.

21

860-865

2008

-

1

-

2

-

1

-

1

-

2

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

709236

Ye

Cellular and molecular mechani ...

Homo sapiens

J. Cell. Mol. Med.

12

1331-1346

2008

-

2

-

1

-

1

-

2

-

1

-

1

-

1

-

1

-

1

-

1

-

673994

Behling-Kelly

Viable 'Haemophilus somnus' in ...

Bos taurus

Infect. Immun.

75

4572-4581

2007

1

-

1

-

1

-

2

-

2

-

4

-

3

-

2

-

1

-

1

-

1

-

1

-

1

-

2

-

4

-

3

-

674829

Ryder

Enhanced skeletal muscle contr ...

Oryctolagus cuniculus

J. Biol. Chem.

282

20447-20454

2007

2

-

1

-

1

-

2

-

1

-

2

-

1

-

2

-

3

-

1

-

2

-

1

-

1

-

2

-

1

-

1

-

2

-

675068

Seguchi

A cardiac myosin light chain k ...

Danio rerio, Homo sapiens

J. Clin. Invest.

117

2812-2824

2007

-

2

-

1

-

2

-

3

-

4

-

7

-

5

-

6

-

2

-

2

-

1

-

2

-

3

-

7

-

5

-

675212

Afonso

Human blood-brain barrier disr ...

Homo sapiens

J. Immunol.

179

2576-2583

2007

2

-

1

-

1

-

2

-

7

-

1

-

2

-

2

-

1

-

1

-

7

-

1

-

677138

Reynoso

A role for long chain myosin l ...

Mus musculus

Shock

28

589-595

2007

1

-

1

-

1

-

1

-

3

-

1

-

2

-

4

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

2

-

671222

Herring

Regulation of and telokin expr ...

Mus musculus

Am. J. Physiol.

291

C817-C827

2006

1

-

1

-

1

-

1

-

2

-

1

-

1

-

1

-

1

-

1

-

2

-

1

-

671753

Niggli

Differential roles of Rho-kina ...

Homo sapiens

Biochem. Biophys. Res. Commun.

343

602-608

2006

-

3

-

1

-

2

-

2

-

1

-

3

-

2

1

-

1

-

1

-

1

-

3

-

1

-

2

-

1

-

3

-

1

-

1

-

672981

Dudnakova

Myosin light chain kinase colo ...

Gallus gallus, Homo sapiens

Cell Motil. Cytoskeleton

63

375-383

2006

-

3

1

-

2

-

2

-

4

-

2

-

4

-

1

-

1

-

3

1

-

2

-

4

-

2

-

672984

Yang

Microfilament-binding properti ...

Oryctolagus cuniculus

Cell Res.

16

367-376

2006

1

-

1

-

1

-

1

-

2

-

1

-

1

-

1

-

3

-

2

1

-

1

-

1

-

1

-

1

-

1

-

1

-

2

-

1

-

1

-

3

-

1

-

1

-

673432

Gu

Inhibiting myosin light chain ...

Mus musculus, Rattus norvegicus

Eur. J. Cancer

42

948-957

2006

-

2

-

2

-

5

-

2

-

2

-

4

-

2

-

2

-

2

-

2

-

674065

Zhu

-

Expression of myosin light cha ...

Rattus norvegicus

Int. J. Mol. Sci.

7

510-518

2006

-

1

-

1

-

1

-

1

-

2

-

1

-

1

-

1

-

675010

Connell

Myosin light chain kinase play ...

Mus musculus

J. Cell Sci.

119

2269-2281

2006

-

1

-

1

-

3

-

1

-

2

-

1

-

1

-

3

-

2

-

1

-

1

-

1

-

3

-

1

-

2

-

1

-

3

-

675541

Tokuoka

Myosin light chain kinase is n ...

Rattus norvegicus

J. Neurosci.

26

11606-11614

2006

-

1

-

1

-

2

-

1

-

3

-

2

-

2

-

1

-

1

-

1

-

1

-

2

-

3

-

2

-

675623

Shimizu

Ca2+-calmodulin-dependent myos ...

Homo sapiens

J. Physiol.

570

219-235

2006

1

-

1

-

1

-

1

-

2

-

4

-

3

-

4

-

6

-

1

-

2

-

2

-

2

-

2

-

4

-

3

-

4

-

675729

Blair

Epithelial myosin light chain ...

Homo sapiens

Lab. Invest.

86

191-201

2006

-

1

-

2

-

3

-

5

-

3

-

2

-

1

-

1

-

1

-

2

-

5

-

3

-

675888

Lucero

A global, myosin light chain k ...

Lytechinus pictus

Mol. Biol. Cell

17

4093-4104

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J. Biol. Chem.

263

10510-10516

1988

-

1

-

1

-

3

-

2

-

1

-

1

-

1

-

1

-

2

-

1

-

640623

Bartelt

Purification, characterization ...

Bos taurus

Biochem. J.

247

747-756

1987

-

2

1

3

1

2

1

-

4

-

2

-

13

1

-

1

-

1

-

2

-

1

-

3

1

2

1

-

2

-

13

1

-

640624

Yamazaki

Purification of caldesmon and ...

Bos taurus, Gallus gallus

J. Biochem.

101

1-9

1987

-

2

1

2

-

3

-

6

1

-

12

2

-

2

-

2

-

2

1

2

-

6

1

-

12

2

-

491223

Takio

Amino acid sequence of rabbit ...

Oryctolagus cuniculus

Biochemistry

25

8049-8057

1986

-

1

-

2

-

2

-

1

-

2

-

1

-

2

-

1

-

491240

Guerriero

Domain organization of chicken ...

Gallus gallus

Biochemistry

25

8372-8381

1986

-

1

-

1

-

3

-

2

-

1

-

3

-

1

-

1

-

2

-

1

-

640619

Serventi

Characterization of myosin lig ...

Bos taurus

Arch. Biochem. Biophys.

245

379-388

1986

1

-

1

2

1

-

2

1

-

2

-

2

-

7

-

1

-

1

-

1

-

1

-

2

-

1

-

2

1

-

2

-

7

-

640645

Stull

-

Calmoduline-dependent protein ...

Bos taurus, Canis lupus familiaris, Cavia porcellus, Gallus gallus, Homo sapiens, Meleagris gallopavo, Rattus norvegicus

The Enzymes, 3rd. Ed. (Boyer, P. D. , Krebs, E. G. , eds. )

17

113-166

1986

-

7

-

7

9

7

-

7

-

7

-

25

-

83

14

-

7

-

7

-

7

-

7

9

7

-

7

-

25

-

83

14

-

491222

Takio

Amino acid sequence of an acti ...

Oryctolagus cuniculus

Biochemistry

24

6028-6037

1985

-

1

-

2

-

2

-

1

-

2

-

1

-

2

-

1

-

640633

Nunnally

Characterization of chicken sk ...

Gallus gallus, Oryctolagus cuniculus

J. Biol. Chem.

260

1020-1026

1985

-

6

-

2

-

2

-

5

-

2

-

8

1

-

14

-

2

-

2

-

6

-

2

-

2

-

2

-

8

1

-

14

-

640615

Nagamoto

Properties of myosin light cha ...

Oryctolagus cuniculus

J. Biochem.

95

1119-1130

1984

-

1

2

-

1

3

1

-

2

-

1

-

2

1

-

2

-

1

-

3

-

1

-

1

-

1

-

1

-

2

-

2

-

1

3

1

-

1

-

2

1

-

2

1

-

3

-

1

-

640635

Bailin

Structure and function of a ca ...

Bos taurus, Gallus gallus, Meleagris gallopavo, Oryctolagus cuniculus

Experientia

40

1185-1188

1984

-

12

-

4

-

4

-

10

-

20

4

-

1

-

4

-

4

-

12

-

4

-

10

-

20

4

-

1

-

640637

Sellers

Purification of myosin light c ...

Limulus sp.

Biochemistry

23

5821-5826

1984

2

-

1

-

1

2

1

-

3

-

1

-

2

-

9

1

-

1

-

2

-

1

-

1

-

1

2

1

-

1

-

2

-

9

1

-

640627

Higashi

Purification and characterizat ...

Sus scrofa

Biochim. Biophys. Acta

747

232-240

1983

2

-

1

-

2

-

1

-

2

1

10

1

-

1

-

2

-

1

-

1

-

1

-

1

-

2

1

10

1

-

640620

Walsh

Bovine stomach myosin light ch ...

Bos taurus, Gallus gallus, Meleagris gallopavo

Biochemistry

21

6890-6896

1982

-

3

-

3

4

3

-

5

-

1

-

7

2

-

6

3

-

3

-

3

-

3

-

3

4

3

-

1

-

7

2

-

6

3

-

640631

Adelstein

-

Purification of smooth muscle ...

Homo sapiens, Meleagris gallopavo

Methods Enzymol.

85

298-308

1982

-

4

-

2

-

2

-

1

-

1

-

12

2

-

2

-

2

-

4

-

2

-

1

-

1

-

12

2

-

640616

Yang

Purification of myosin light c ...

Oryctolagus cuniculus

Pediatr. Res.

15

229-234

1981

-

1

-

2

-

1

-

2

-

2

-

1

-

1

-

2

-

2

-

640630

Adelstein

Purification and characterizat ...

Meleagris gallopavo

J. Biol. Chem.

256

7501-7509

1981

-

2

-

2

1

3

1

-

2

-

1

-

3

1

2

10

1

-

1

-

1

-

1

-

2

-

2

1

3

1

-

1

-

3

1

2

10

1

-

640622

Wolf

Purification of myosin light c ...

Bos taurus

Proc. Natl. Acad. Sci. USA

77

5852-5855

1980

-

1

2

-

1

-

2

-

2

1

-

2

1

-

1

-

1

-

1

-

1

-

2

-

1

-

2

1

-

2

1

-

640618

Hathaway

Human platelet myosin light ch ...

Homo sapiens

Proc. Natl. Acad. Sci. USA

76

1653-1657

1979

-

1

2

1

-

3

-

1

-

2

1

-

9

1

-

1

-

1

-

1

-

1

-

1

-

2

1

-

1

-

2

1

-

9

1

-

1

-

640621

Walsh

Purification and characterizat ...

Bos taurus

J. Biol. Chem.

254

12136-12144

1979

2

-

1

2

1

-

2

-

3

-

13

1

-

1

-

1

-

2

-

1

-

1

-

1

2

1

-

3

-

13

1

-

1

-

640614

Pires

Purification and properties of ...

Oryctolagus cuniculus

Biochem. J.

167

137-146

1977

1

-

5

1

2

1

-

2

-

1

-

2

1

-

15

1

-

1

-

1

2

-

1

-

5

-

1

2

1

-

1

-

2

1

-

15

1

-

1

2

-

640613

Pires

Myosin light-chain kinase, a n ...

Oryctolagus cuniculus

FEBS Lett.

41

292-296

1974

1

-

2

-

1

-

1

-

1

-

2

1

-

9

1

-

2

-

1

-

1

-

2

-

1

-

1

-

2

1

-

9

1

2

-

1

-

Inhibition of myosin light chain kinase reduces brain edema formation after traumatic brain injury

Data extracted from this reference: