Cloned (Comment) | Organism |
---|---|
cloning and recombinant expression of functionally active CAMKIV kinase domain | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | calcium-calmodulin dependent signalling via Ca2+ leads to activation of CAMKIV autoinhibition | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | calcium-calmodulin dependent signalling via Ca2+ leads to activation of CAMKIV autoinhibition | Homo sapiens | |
Mg2+ | required | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a protein | Homo sapiens | - |
ADP + a phosphoprotein | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q16566 | - |
- |
Purification (Comment) | Organism |
---|---|
recombinant functionally active CAMKIV kinase domain | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + a protein | - |
Homo sapiens | ADP + a phosphoprotein | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | CAMKIV structure-function analysis, pH dependence, molecular dynamics simulations and three-dimensional structure analysis, overview | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
calcium/calmodulin-dependent protein kinase IV | - |
Homo sapiens |
CaMKIV | - |
Homo sapiens |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
5 | 11.5 | within the pH range, CAMKIV maintains both its secondary and tertiary structures, along with its function, whereas significant aggregation is observed at acidic pH 2.0-4.5 | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens | |
Calmodulin | calcium-calmodulin dependent signalling via Ca2+ leads to activation of CAMKIV autoinhibition | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
evolution | calcium/calmodulin-dependent protein kinase IV (CAMKIV) is a member of Ser/Thr protein kinase family | Homo sapiens |
malfunction | overexpression and mutation in CAMKIV as well as change in Ca2+ concentration is associated with numerous neurodegenerative diseases and cancers | Homo sapiens |
additional information | CAMKIV structure-function analysis, pH dependence, molecular dynamics simulations and three-dimensional structure analysis, overview | Homo sapiens |
physiological function | enzyme CAMKIV is regulated by the calcium-calmodulin dependent signal through a secondary messenger, Ca2+, which leads to the activation of its autoinhibited form | Homo sapiens |