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Literature summary for 2.7.11.17 extracted from

  • Naz, H.; Shahbaaz, M.; Bisetty, K.; Islam, A.; Ahmad, F.; Hassan, M.I.
    Effect of pH on the structure, function, and stability of human calcium/calmodulin-dependent protein kinase IV: combined spectroscopic and MD simulation studies (2016), Biochem. Cell Biol., 94, 221-228.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
cloning and recombinant expression of functionally active CAMKIV kinase domain Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information calcium-calmodulin dependent signalling via Ca2+ leads to activation of CAMKIV autoinhibition Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ calcium-calmodulin dependent signalling via Ca2+ leads to activation of CAMKIV autoinhibition Homo sapiens
Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + a protein Homo sapiens
-
ADP + a phosphoprotein
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q16566
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant functionally active CAMKIV kinase domain Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a protein
-
Homo sapiens ADP + a phosphoprotein
-
?

Subunits

Subunits Comment Organism
More CAMKIV structure-function analysis, pH dependence, molecular dynamics simulations and three-dimensional structure analysis, overview Homo sapiens

Synonyms

Synonyms Comment Organism
calcium/calmodulin-dependent protein kinase IV
-
Homo sapiens
CaMKIV
-
Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
5 11.5 within the pH range, CAMKIV maintains both its secondary and tertiary structures, along with its function, whereas significant aggregation is observed at acidic pH 2.0-4.5 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens
Calmodulin calcium-calmodulin dependent signalling via Ca2+ leads to activation of CAMKIV autoinhibition Homo sapiens

General Information

General Information Comment Organism
evolution calcium/calmodulin-dependent protein kinase IV (CAMKIV) is a member of Ser/Thr protein kinase family Homo sapiens
malfunction overexpression and mutation in CAMKIV as well as change in Ca2+ concentration is associated with numerous neurodegenerative diseases and cancers Homo sapiens
additional information CAMKIV structure-function analysis, pH dependence, molecular dynamics simulations and three-dimensional structure analysis, overview Homo sapiens
physiological function enzyme CAMKIV is regulated by the calcium-calmodulin dependent signal through a secondary messenger, Ca2+, which leads to the activation of its autoinhibited form Homo sapiens