Cloned (Comment) | Organism |
---|---|
gene CMK1, real-time RT-PCR expression analysis | Candida albicans |
gene CMK2, real-time RT-PCR expression analysis | Candida albicans |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction the cmk1DELTA/DELTA, the cmk2DELTA/DELTA and the cmk1DELTA/DELTA-cmk2DELTA/DELTA deletion mutants. CaMK mutants show no growth defect | Candida albicans |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell wall | - |
Candida albicans | 5618 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Candida albicans | Q59XV1 | - |
- |
Candida albicans | Q5ANJ0 | - |
- |
Candida albicans BWP17 | Q59XV1 | - |
- |
Candida albicans BWP17 | Q5ANJ0 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
CaMK | - |
Candida albicans |
CMK1 | - |
Candida albicans |
CMK2 | - |
Candida albicans |
type II Ca2+/calmodulin-dependent protein kinase | - |
Candida albicans |
General Information | Comment | Organism |
---|---|---|
malfunction | loss of either CMK1 or CMK2, or both results in increased expression of cell wall integrity-related genes under Calcofluor white (CFW) treatment. Disruption of either CMK1 or CMK2, or both not only leads to a significant increase of intracellular reactive oxygen species levels, but also leads to a decrease of the mitochondrial membrane potential, suggesting the important roles that CaMKs play in the maintenance of the mitochondrial function. The expression of PGA13, ECM331, DFG5 and CRH11 in cmk2DELTA/DELTA and cmk1DELTA/Dcmk2DELTA/DELTA cells is remarkably upregulated compared with the wild-type strain, while no obvious differences are observed in cmk1DELTA/DELTA cells | Candida albicans |
physiological function | type II Ca2+/calmodulin-dependent protein kinases are involved in the regulation of cell wall integrity and oxidative stress response in Candida albicans. CaMKs are essential for the maintenance of cellular redox balance. CaMKs are important for cell wall integrity under conditions of cell wall stress, and Cmk2 seems to be the main contributor in Candida albicans | Candida albicans |
physiological function | type II Ca2+/calmodulin-dependent protein kinases are involved in the regulation of cell wall integrity and oxidative stress response in Candida albicans. CaMKs are essential for the maintenance of cellular redox balance. CaMKs are important for cell wall integrity under conditions of cell wall stress, but Cmk1 seems not to be the main contributor in Candida albicans | Candida albicans |