Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.17 extracted from

  • Ding, X.; Yu, Q.; Zhang, B.; Xu, N.; Jia, C.; Dong, Y.; Chen, Y.; Xing, L.; Li, M.
    The type II Ca2+/calmodulin-dependent protein kinases are involved in the regulation of cell wall integrity and oxidative stress response in Candida albicans (2014), Biochem. Biophys. Res. Commun., 446, 1073-1078.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene CMK1, real-time RT-PCR expression analysis Candida albicans
gene CMK2, real-time RT-PCR expression analysis Candida albicans

Protein Variants

Protein Variants Comment Organism
additional information construction the cmk1DELTA/DELTA, the cmk2DELTA/DELTA and the cmk1DELTA/DELTA-cmk2DELTA/DELTA deletion mutants. CaMK mutants show no growth defect Candida albicans

Localization

Localization Comment Organism GeneOntology No. Textmining
cell wall
-
Candida albicans 5618
-

Organism

Organism UniProt Comment Textmining
Candida albicans Q59XV1
-
-
Candida albicans Q5ANJ0
-
-
Candida albicans BWP17 Q59XV1
-
-
Candida albicans BWP17 Q5ANJ0
-
-

Synonyms

Synonyms Comment Organism
CaMK
-
Candida albicans
CMK1
-
Candida albicans
CMK2
-
Candida albicans
type II Ca2+/calmodulin-dependent protein kinase
-
Candida albicans

General Information

General Information Comment Organism
malfunction loss of either CMK1 or CMK2, or both results in increased expression of cell wall integrity-related genes under Calcofluor white (CFW) treatment. Disruption of either CMK1 or CMK2, or both not only leads to a significant increase of intracellular reactive oxygen species levels, but also leads to a decrease of the mitochondrial membrane potential, suggesting the important roles that CaMKs play in the maintenance of the mitochondrial function. The expression of PGA13, ECM331, DFG5 and CRH11 in cmk2DELTA/DELTA and cmk1DELTA/Dcmk2DELTA/DELTA cells is remarkably upregulated compared with the wild-type strain, while no obvious differences are observed in cmk1DELTA/DELTA cells Candida albicans
physiological function type II Ca2+/calmodulin-dependent protein kinases are involved in the regulation of cell wall integrity and oxidative stress response in Candida albicans. CaMKs are essential for the maintenance of cellular redox balance. CaMKs are important for cell wall integrity under conditions of cell wall stress, and Cmk2 seems to be the main contributor in Candida albicans Candida albicans
physiological function type II Ca2+/calmodulin-dependent protein kinases are involved in the regulation of cell wall integrity and oxidative stress response in Candida albicans. CaMKs are essential for the maintenance of cellular redox balance. CaMKs are important for cell wall integrity under conditions of cell wall stress, but Cmk1 seems not to be the main contributor in Candida albicans Candida albicans