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Literature summary for 2.7.11.17 extracted from

  • Ashpole, N.M.; Herren, A.W.; Ginsburg, K.S.; Brogan, J.D.; Johnson, D.E.; Cummins, T.R.; Bers, D.M.; Hudmon, A.
    Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites (2012), J. Biol. Chem., 287, 19856-19869.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine enzyme-dependent alterations in Na+ channel gating may cause arrhythmogenesis in many millions of people carrying the clinical diagnosis of heart failure Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + human cardiac sodium channel NaV1.5 Rattus norvegicus the intracellular loop between domains 1 and 2 of cardiac sodium channel NaV1.5 is phosphorylated specifically at the Ser516 and Thr594 sites. The phosphorylation status of Ser516 and Thr594 on cardiac sodium channel NaV1.5, is an important mediator of the enzyme-dependent negative shift in cardiac sodium channel NaV1.5 ADP + phosphorylated human cardiac sodium channel NaV1.5
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + human cardiac sodium channel NaV1.5 the intracellular loop between domains 1 and 2 of cardiac sodium channel NaV1.5 is phosphorylated specifically at the Ser516 and Thr594 sites. The phosphorylation status of Ser516 and Thr594 on cardiac sodium channel NaV1.5, is an important mediator of the enzyme-dependent negative shift in cardiac sodium channel NaV1.5 Rattus norvegicus ADP + phosphorylated human cardiac sodium channel NaV1.5
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 ?
ATP + human cardiac sodium channel NaV1.5 the intracellular loop between domains 1 and 2 of cardiac sodium channel NaV1.5 is phosphorylated specifically at the Ser516 and Thr594 sites Rattus norvegicus ADP + phosphorylated human cardiac sodium channel NaV1.5
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 ?

Synonyms

Synonyms Comment Organism
CaMKII
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 Rattus norvegicus