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Literature summary for 2.7.11.17 extracted from
- Neuroprotection by neurotrophic factors and membrane depolarization is regulated by calmodulin kinase IV (2008), J. Biol. Chem., 283, 4133-4144.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in HEK-293T cells | Gallus gallus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| K60E | mutant is kinase dead | Gallus gallus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Gallus gallus | 5829 | - |
| nucleus | mainly localized in the nucleus | Gallus gallus | 5634 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | dependent on, 2 mM CaCl2 plus 0.001 mM calmodulin induce 69.2% activation of CaMKIV activity | Gallus gallus |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 40000 | - |
SDS-PAGE | Gallus gallus |
| 41300 | - |
estimated from amino acid sequence | Gallus gallus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Gallus gallus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| anti-FLAG-Sepharose chromatography | Gallus gallus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| motoneuron | - |
Gallus gallus | - |
| spinal cord | - |
Gallus gallus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + cAMP response element binding protein | - |
Gallus gallus | ADP + phosphorylated cAMP response element binding protein | - |
? | |
| ATP + phosphatidylinositol 3-kinase | - |
Gallus gallus | ADP + phosphorylated phosphatidylinositol 3-kinase | - |
? | |
| ATP + protein kinase B | - |
Gallus gallus | ADP + phosphorylated protein kinase B | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Ca2+/CaM-dependent protein kinase | - |
Gallus gallus |
| calmodulin kinase IV | - |
Gallus gallus |
| CaMKIV | - |
Gallus gallus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Gallus gallus | |
| Calmodulin | dependent on, 2 mM CaCl2 plus 0.001 mM calmodulin induce 69.2% activation of CaMKIV activity | Gallus gallus | |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Gallus gallus | estimated from amino acid sequence | - |
8.28 |
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Release 2023.1 (January 2023)
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