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Literature summary for 2.7.11.17 extracted from

  • Grant, P.A.; Best, S.L.; Sanmugalingam, N.; Alessio, R.; Jama, A.M.; Toeroek, K.
    A two-state model for Ca2+/CaM-dependent protein kinase II (alphaCaMKII) in response to persistent Ca2+ stimulation in hippocampal neurons (2008), Cell Calcium, 44, 465-478.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
T286A mutant clustering behaviour is similar compared to the wild type enzyme Rattus norvegicus
T286D mutant mimics autophosphorylation at Thr286 Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
KN-93 membrane permeant inhibitor of alphaCaMKII binding to Ca2+/calmodulin Rattus norvegicus
additional information not affected by myristoyl-RRKEQKTGHAVRAIGRE Rattus norvegicus
myristoylated autocamtide-2-related inhibitory peptide
-
Rattus norvegicus
myristoylated Trp peptide 0.0135 mM prevents alphaCaMKII clustering Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ dependent on Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P11275
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hippocampus
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Thr286-autophosphorylation is antagonistic to CaMKII clustering Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
alphaCa2+/CaM-dependent protein kinase II
-
Rattus norvegicus
alphaCaMKII
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Rattus norvegicus
Calmodulin dependent on Rattus norvegicus