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Literature summary for 2.7.11.17 extracted from

  • Ang, E.S.; Zhang, P.; Steer, J.H.; Tan, J.W.; Yip, K.; Zheng, M.H.; Joyce, D.A.; Xu, J.
    Calcium/calmodulin-dependent kinase activity is required for efficient induction of osteoclast differentiation and bone resorption by receptor activator of nuclear factor kappa B ligand (RANKL) (2007), J. Cell. Physiol., 212, 787-795.
    View publication on PubMed
Search for more literature for 2.7.11.17

Activating Compound

Activating Compound Comment Organism Structure
Calmodulin
-
 Mus musculus
receptor activator of nuclear factor kappa B ligand
-
 Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
KN62 reversible inhibition, causes inhibition of osteoclast formation in vivo Mus musculus
KN93 reversible inhibition, causes inhibition of osteoclast formation in vivo Mus musculus
additional information no inhibition of CaMKII by KN92 Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required Mus musculus
Mg2+
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + protein CREB Mus musculus activation by phosphorylation ADP + phosphorylated protein CREB
-
 ?
ATP + protein CREB Mus musculus C57/Bl activation by phosphorylation ADP + phosphorylated protein CREB
-
 ?
ATP + protein ERK Mus musculus activation by phosphorylation ADP + phosphorylated protein ERK
-
 ?
ATP + protein ERK Mus musculus C57/Bl activation by phosphorylation ADP + phosphorylated protein ERK
-
 ?
additional information Mus musculus CaMK activity is required for efficient induction of osteoclast differentiation and bone resorption by receptor activator of nuclear factor kappa B ligand, RANKL, overview ?
-
 ?
additional information Mus musculus C57/Bl CaMK activity is required for efficient induction of osteoclast differentiation and bone resorption by receptor activator of nuclear factor kappa B ligand, RANKL, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q923T9 C57/Bl mice
-
Mus musculus C57/Bl Q923T9 C57/Bl mice
-

Source Tissue

Source Tissue Comment Organism Textmining
BBM cell receptor activator of nuclear factor kappa B ligand-differentiated, expression of CaMKI and CaMKIIgamma Mus musculus
-
bone marrow
-
 Mus musculus
-
brain expression of CaMKI, CaMKII alpha, beta, gamma and delta, and CaMKIV Mus musculus
-
osteoclast
-
 Mus musculus
-
RAW264.7 cell receptor activator of nuclear factor kappa B ligand-differentiated, expression of CaMKI, CaMKIIgamma and also of CaMKIV at minimum level Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + protein CREB activation by phosphorylation Mus musculus ADP + phosphorylated protein CREB
-
 ?
ATP + protein CREB activation by phosphorylation Mus musculus C57/Bl ADP + phosphorylated protein CREB
-
 ?
ATP + protein ERK activation by phosphorylation Mus musculus ADP + phosphorylated protein ERK
-
 ?
ATP + protein ERK activation by phosphorylation Mus musculus C57/Bl ADP + phosphorylated protein ERK
-
 ?
additional information CaMK activity is required for efficient induction of osteoclast differentiation and bone resorption by receptor activator of nuclear factor kappa B ligand, RANKL, overview Mus musculus ?
-
 ?
additional information CaMK activity is required for efficient induction of osteoclast differentiation and bone resorption by receptor activator of nuclear factor kappa B ligand, RANKL, overview Mus musculus C57/Bl ?
-
 ?

Synonyms

Synonyms Comment Organism
calcium/calmodulin-dependent kinase
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus