Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Calmodulin | - |
Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression of CaMKII in HEK-293 cells, and expression of CaMKII in cultured neurons using lentiviral transfection, co-expression of protein substrates | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
KN-93 | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | - |
Homo sapiens | |
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + glutamate receptor subunit GluR1 | Homo sapiens | low activity, CaMKII, membrane localization of GluR1 restricts its phosphorylation | ADP + phosphorylated glutamate receptor subunit GluR1 | - |
? | |
ATP + glutamate receptor subunit NR2B | Homo sapiens | low activity, CaMKII | ADP + phosphorylated glutamate receptor subunit NR2B | - |
? | |
ATP + PSD-95 | Homo sapiens | high activity, CaMKII, smaller synapses show greater variability in PSD-95 phosphorylation | ADP + phosphorylated PSD-95 | - |
? | |
ATP + Stargazin | Homo sapiens | high activity, CaMKII, phosphatases limit phosphorylation of stargazin | ADP + phosphorylated Stargazin | - |
? | |
additional information | Homo sapiens | CaMKII is a major component of the postsynaptic density of excitatory synapses, and plays a key role in the regulation of synaptic function in the mammalian brain, the unique molecular architecture of the postsynaptic density results in highly selective substrate discrimination by CaMKII, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
neuron | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + glutamate receptor subunit GluR1 | low activity, CaMKII, membrane localization of GluR1 restricts its phosphorylation | Homo sapiens | ADP + phosphorylated glutamate receptor subunit GluR1 | - |
? | |
ATP + glutamate receptor subunit GluR1 | phosphorylation at Ser831 | Homo sapiens | ADP + phosphorylated glutamate receptor subunit GluR1 | - |
? | |
ATP + glutamate receptor subunit NR2B | - |
Homo sapiens | ADP + phosphorylated glutamate receptor subunit NR2B | - |
? | |
ATP + glutamate receptor subunit NR2B | low activity, CaMKII | Homo sapiens | ADP + phosphorylated glutamate receptor subunit NR2B | - |
? | |
ATP + PSD-95 | high activity, CaMKII, smaller synapses show greater variability in PSD-95 phosphorylation | Homo sapiens | ADP + phosphorylated PSD-95 | - |
? | |
ATP + PSD-95 | a protein implicated in the scaffolding and trafficking of AMPA receptors | Homo sapiens | ADP + phosphorylated PSD-95 | - |
? | |
ATP + Stargazin | high activity, CaMKII, phosphatases limit phosphorylation of stargazin | Homo sapiens | ADP + phosphorylated Stargazin | - |
? | |
ATP + Stargazin | a protein implicated in the scaffolding and trafficking of AMPA receptors | Homo sapiens | ADP + phosphorylated Stargazin | - |
? | |
additional information | CaMKII is a major component of the postsynaptic density of excitatory synapses, and plays a key role in the regulation of synaptic function in the mammalian brain, the unique molecular architecture of the postsynaptic density results in highly selective substrate discrimination by CaMKII, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
calcium/calmodulin-dependent protein kinase II | - |
Homo sapiens |
CaMKII | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |