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Literature summary for 2.7.11.17 extracted from

  • Takeda, H.; Kitaoka, Y.; Hayashi, Y.; Kumai, T.; Munemasa, Y.; Fujino, H.; Kobayashi, S.; Ueno, S.
    Calcium/calmodulin-dependent protein kinase II regulates the phosphorylation of CREB in NMDA-induced retinal neurotoxicity (2007), Brain Res., 1184, 306-3015.
    View publication on PubMed
Search for more literature for 2.7.11.17

Activating Compound

Activating Compound Comment Organism Structure
Calmodulin
-
 Rattus norvegicus
additional information N-methyl-D-aspartate-induced neurotoxicity in the rat retina leads to increased levels of phopshorylated CaMKII and susequently of phosphorylated CREB, overview Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information CaMKII downregulation by CaMKII small interfering RNA in retinal cells Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
 Rattus norvegicus
Mg2+
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + protein CREB Rattus norvegicus CaMKII regulates the phosphorylation of CREB in NMDA-induced retinal neurotoxicity ADP + phosphorylated protein CREB
-
 ?
additional information Rattus norvegicus N-methyl-D-aspartate-induced neurotoxicity in the rat retina leads to increased levels of phopshorylated CaMKII and susequently of phosphorylated CREB, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neuron
-
 Rattus norvegicus
-
retina
-
 Rattus norvegicus
-
retinal ganglion cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + protein CREB CaMKII regulates the phosphorylation of CREB in NMDA-induced retinal neurotoxicity Rattus norvegicus ADP + phosphorylated protein CREB
-
 ?
ATP + protein CREB i.e. cyclic AMP-response element binding protein Rattus norvegicus ADP + phosphorylated protein CREB
-
 ?
additional information N-methyl-D-aspartate-induced neurotoxicity in the rat retina leads to increased levels of phopshorylated CaMKII and susequently of phosphorylated CREB, overview Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
calcium/calmodulin-dependent protein kinase II
-
 Rattus norvegicus
CaMKII
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus