Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of transgenic mice expressing the AIP inhibitory peptide in cardiomyocytes nuclei, the inhibitor affects the nuclear enzyme, but not the cytoplasmic enzyme, which inhibits the translocation of protein HDAC5 from nucleus to cytoplasm, phenotype, overview | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
AIP peptide | a CaMKII inhibitory peptide with the sequence KKALRRQEAVDAL | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Mus musculus | 5737 | - |
nucleus | - |
Mus musculus | 5634 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + NFkappaB | Mus musculus | the nuclear CaMKII does not phosphorylate, in contrast to the cytoplasmic isozyme, CREB at S133 and NFkappaB at S536 | ADP + phosphorylated NFkappaB | - |
? | |
ATP + protein CREB | Mus musculus | the nuclear CaMKII does not phosphorylate, in contrast to the cytoplasmic isozyme, CREB at S133 and NFkappaB at S536 | ADP + phosphorylated protein CREB | - |
? | |
ATP + protein HDAC | Mus musculus | phosphorylation by nuclear CaMKII results in HDAC translocation from nucleus to cytoplasm | ADP + phosphorylated protein HDAC | - |
? | |
ATP + protein PLN | Mus musculus | PLN regulation through phosphorylation by CaMKII at Thr17 | ADP + phosphorylated Pprotein LN | - |
? | |
additional information | Mus musculus | CaMKII is critical in regulating myocyte function with regard to excitation-contraction-relaxation cycles and excitation-transcription coupling | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + NFkappaB | the nuclear CaMKII does not phosphorylate, in contrast to the cytoplasmic isozyme, CREB at S133 and NFkappaB at S536 | Mus musculus | ADP + phosphorylated NFkappaB | - |
? | |
ATP + protein CREB | the nuclear CaMKII does not phosphorylate, in contrast to the cytoplasmic isozyme, CREB at S133 and NFkappaB at S536 | Mus musculus | ADP + phosphorylated protein CREB | - |
? | |
ATP + protein HDAC | phosphorylation by nuclear CaMKII results in HDAC translocation from nucleus to cytoplasm | Mus musculus | ADP + phosphorylated protein HDAC | - |
? | |
ATP + protein HDAC | nuclear CaMKII | Mus musculus | ADP + phosphorylated protein HDAC | - |
? | |
ATP + protein PLN | PLN regulation through phosphorylation by CaMKII at Thr17 | Mus musculus | ADP + phosphorylated Pprotein LN | - |
? | |
ATP + protein PLN | a sarcoplasmic reticulum protein, phosphorylation by CaMKII at Thr17 | Mus musculus | ADP + phosphorylated protein PLN | - |
? | |
additional information | CaMKII is critical in regulating myocyte function with regard to excitation-contraction-relaxation cycles and excitation-transcription coupling | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CaMKII | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |