Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.17 extracted from

  • Li, B.; Dedman, J.R.; Kaetzel, M.A.
    Nuclear Ca2+/calmodulin-dependent protein kinase II in the murine heart (2006), Biochim. Biophys. Acta, 1763, 1275-1281.
    View publication on PubMed
Search for more literature for 2.7.11.17

Protein Variants

Protein Variants Comment Organism
additional information construction of transgenic mice expressing the AIP inhibitory peptide in cardiomyocytes nuclei, the inhibitor affects the nuclear enzyme, but not the cytoplasmic enzyme, which inhibits the translocation of protein HDAC5 from nucleus to cytoplasm, phenotype, overview Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
AIP peptide a CaMKII inhibitory peptide with the sequence KKALRRQEAVDAL Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Mus musculus 5737
-
nucleus
-
 Mus musculus 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + NFkappaB Mus musculus the nuclear CaMKII does not phosphorylate, in contrast to the cytoplasmic isozyme, CREB at S133 and NFkappaB at S536 ADP + phosphorylated NFkappaB
-
 ?
ATP + protein CREB Mus musculus the nuclear CaMKII does not phosphorylate, in contrast to the cytoplasmic isozyme, CREB at S133 and NFkappaB at S536 ADP + phosphorylated protein CREB
-
 ?
ATP + protein HDAC Mus musculus phosphorylation by nuclear CaMKII results in HDAC translocation from nucleus to cytoplasm ADP + phosphorylated protein HDAC
-
 ?
ATP + protein PLN Mus musculus PLN regulation through phosphorylation by CaMKII at Thr17 ADP + phosphorylated Pprotein LN
-
 ?
additional information Mus musculus CaMKII is critical in regulating myocyte function with regard to excitation-contraction-relaxation cycles and excitation-transcription coupling ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + NFkappaB the nuclear CaMKII does not phosphorylate, in contrast to the cytoplasmic isozyme, CREB at S133 and NFkappaB at S536 Mus musculus ADP + phosphorylated NFkappaB
-
 ?
ATP + protein CREB the nuclear CaMKII does not phosphorylate, in contrast to the cytoplasmic isozyme, CREB at S133 and NFkappaB at S536 Mus musculus ADP + phosphorylated protein CREB
-
 ?
ATP + protein HDAC phosphorylation by nuclear CaMKII results in HDAC translocation from nucleus to cytoplasm Mus musculus ADP + phosphorylated protein HDAC
-
 ?
ATP + protein HDAC nuclear CaMKII Mus musculus ADP + phosphorylated protein HDAC
-
 ?
ATP + protein PLN PLN regulation through phosphorylation by CaMKII at Thr17 Mus musculus ADP + phosphorylated Pprotein LN
-
 ?
ATP + protein PLN a sarcoplasmic reticulum protein, phosphorylation by CaMKII at Thr17 Mus musculus ADP + phosphorylated protein PLN
-
 ?
additional information CaMKII is critical in regulating myocyte function with regard to excitation-contraction-relaxation cycles and excitation-transcription coupling Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
CaMKII
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus