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Literature summary for 2.7.11.17 extracted from

  • Xu, G.Y.; Huang, L.Y.
    Ca2+/calmodulin-dependent protein kinase II potentiates ATP responses by promoting trafficking of P2X receptors (2004), Proc. Natl. Acad. Sci. USA, 101, 11868-11873.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
Calmodulin dependent on Rattus norvegicus
additional information electrical stimulation of dorsal root ganglion neurons or the sciatic nerve enhances the CaMKII activity stimulating the P2X3 receptor, overview Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)amino-N-(4-chlorocinnamyl)-N-methylbenzylamine i.e. KN-93, competitive on the Ca2+/calmodulin binding site, CaMKII-specific inhibitor, blocks activation of the P2X3 receptor in neurons Rattus norvegicus
KN-62 competitive on the Ca2+/calmodulin binding site of CaMKII Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ dependent on Rattus norvegicus
Mg2+
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus CaMKII Ca2+/calmodulin-dependently potentiates ATP responses by promoting trafficking of P2X3 receptors, electrical stimulation of dorsal root ganglion neurons or the sciatic nerve enhances the CaMKII-dependent receptor expression in membranes, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 Sprague-Dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
spinal ganglion
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information CaMKII Ca2+/calmodulin-dependently potentiates ATP responses by promoting trafficking of P2X3 receptors, electrical stimulation of dorsal root ganglion neurons or the sciatic nerve enhances the CaMKII-dependent receptor expression in membranes, overview Rattus norvegicus ?
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 ?

Synonyms

Synonyms Comment Organism
Ca2+/calmodulin-dependent protein kinase II
-
 Rattus norvegicus
CaMKII
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus