Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.17 extracted from

  • Hudmon, A.; Lebel, E.; Roy, H.; Sik, A.; Schulman, H.; Waxham, M.N.; De Koninck, P.
    A mechanism for Ca2+/calmodulin-dependent protein kinase II clustering at synaptic and nonsynaptic sites based on self-association (2005), J. Neurosci., 25, 6971-6983.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.17

Activating Compound

Activating Compound Comment Organism Structure
Calmodulin dependent on, Ca2+/calmodulin-dependent, reversible enzyme clustering by self-association of the recombinant CaMKII, which might be hindered by autophosphorylation at Thr286, mechanism, overview Rattus norvegicus
ionomycin
-
 Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
expression of GFP-tagged wild-type and mutant CaMKII in neuronal cultures and in HEK-293 cells, pH-dependent, Ca2+/calmodulin-dependent, reversible enzyme clustering by self-association of the recombinant CaMKII, which might be hindered by autophosphorylation at Thr286, mechanism, overview Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
I205K site-directed mutagenesis, the mutant CaMKII does not undergo self-association in recombinant HEK-293 cells Rattus norvegicus
T286D site-directed mutagenesis, the mutant CaMKII exhibits poor self-association in recombinant HEK-293 cells and is impaired in autophosphorylation Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum perinuclear, a nonsynaptic site Rattus norvegicus 5783
-
additional information glutamate receptor stimulation induces Ca2+-dependent CaMKII translocation to synaptic and nonsynaptic sites Rattus norvegicus
-
-
perinuclear space endoplasmic reticulum Rattus norvegicus
-
-
synapse
-
 Rattus norvegicus 45202
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ dependent on, Ca2+/calmodulin-dependent, reversible enzyme clustering by self-association of the recombinant CaMKII, which might be hindered by autophosphorylation at Thr286, mechanism, overview Rattus norvegicus
Mg2+
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus glutamate receptor stimulation induces Ca2+-dependent CaMKII translocation to synaptic and nonsynaptic sites ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 isozyme CaMKIIalpha
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein CaMKII is autophosphorylated at Thr286 Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
hippocampus
-
 Rattus norvegicus
-
neuron
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information glutamate receptor stimulation induces Ca2+-dependent CaMKII translocation to synaptic and nonsynaptic sites Rattus norvegicus ?
-
 ?
additional information CaMKII performs autophosphorylation at Thr286 Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
alphaCaMKII
-
 Rattus norvegicus
Ca2+/calmodulin-dependent protein kinase II
-
 Rattus norvegicus
CaMKII
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus