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Literature summary for 2.7.11.17 extracted from

  • Schmitt, J.M.; Guire, E.S.; Saneyoshi, T.; Soderling, T.R.
    Calmodulin-dependent kinase kinase/calmodulin kinase I activity gates extracellular-regulated kinase-dependent long-term potentiation (2005), J. Neurosci., 25, 1281-1290.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.17

Activating Compound

Activating Compound Comment Organism Structure
Calmodulin dependent on Mus musculus
Calmodulin dependent on Rattus norvegicus
additional information activating phosphorylation by calmodulin-dependent kinase kinase is required for CaMKI function in long-term potentiation, and learning and memory Mus musculus
additional information activating phosphorylation by calmodulin-dependent kinase kinase is required for CaMKI function in long-term potentiation, and learning and memory Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ has a regulatory function for CaMKI activity Mus musculus
Ca2+ has a regulatory function for CaMKI activity Rattus norvegicus
Mg2+
-
 Mus musculus
Mg2+
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus calmodulin-dependent kinase kinase/calmodulin kinase I activity, not CaMKIV or CaMKII, gates extracellular-signal-regulated kinase-dependent long-term potentiation required for learning and memory, Ras-GRF1 and ERK are also involved, NMDA-dependent activation of ERK, CaMKK pathway regulation, overview ?
-
 ?
additional information Rattus norvegicus calmodulin-dependent kinase kinase/calmodulin kinase I activity, not CaMKIV or CaMKII, gates extracellular-signal-regulated kinase-dependent long-term potentiation required for learning and memory, Ras-GRF1 and ERK are also involved, NMDA-dependent activation of ERK, CaMKK pathway regulation, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 male C57BL/6 mice
-
Rattus norvegicus
-
 Sprague-Dawley rats
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein activating phosphorylation by calmodulin-dependent kinase kinase is required for CaMKI function in long-term potentiation, and learning and memory Mus musculus
phosphoprotein activating phosphorylation by calmodulin-dependent kinase kinase is required for CaMKI function in long-term potentiation, and learning and memory Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
brain
-
 Rattus norvegicus
-
hippocampus neurons Mus musculus
-
hippocampus neurons Rattus norvegicus
-
neuron
-
 Mus musculus
-
neuron
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information calmodulin-dependent kinase kinase/calmodulin kinase I activity, not CaMKIV or CaMKII, gates extracellular-signal-regulated kinase-dependent long-term potentiation required for learning and memory, Ras-GRF1 and ERK are also involved, NMDA-dependent activation of ERK, CaMKK pathway regulation, overview Mus musculus ?
-
 ?
additional information calmodulin-dependent kinase kinase/calmodulin kinase I activity, not CaMKIV or CaMKII, gates extracellular-signal-regulated kinase-dependent long-term potentiation required for learning and memory, Ras-GRF1 and ERK are also involved, NMDA-dependent activation of ERK, CaMKK pathway regulation, overview Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
calmodulin kinase I
-
 Mus musculus
calmodulin kinase I
-
 Rattus norvegicus
CaMKI
-
 Mus musculus
CaMKI
-
 Rattus norvegicus
CaMKII
-
 Mus musculus
CaMKII
-
 Rattus norvegicus
CaMKIV
-
 Mus musculus
CaMKIV
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus
ATP
-
 Rattus norvegicus