Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Calmodulin | dependent on | Homo sapiens | |
Calmodulin | dependent on | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
expressed in GT1-7 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
KN-93 | - |
Homo sapiens | |
KN-93 | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell soma | brain | Rattus norvegicus | - |
- |
cell soma | neuron | Homo sapiens | - |
- |
additional information | distribution in hippocampal neurons: CaM kinase II is located in neurites and neuronal soma | Homo sapiens | - |
- |
neurite | - |
Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | dependent on | Homo sapiens | |
Ca2+ | dependent on | Rattus norvegicus | |
Mg2+ | - |
Homo sapiens | |
Mg2+ | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + tau protein | Rattus norvegicus | phosphorylation at Ser416 by CaM kinase II is high in early stages of brain development | ADP + phosphorylated tau protein | - |
? | |
ATP + tau protein | Homo sapiens | phosphorylation at Ser416 by CaM kinase II is high in early stages of brain development, CaM kinase II is involved in the accumulation of tau in neuronal soma in Alzheimer's disease brain | ADP + phosphorylated tau protein | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozyme CaM kinase IIalpha | - |
Rattus norvegicus | - |
isozyme CaM kinase IIalpha | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | cortex, soma, Alzheimer's disease brain | Homo sapiens | - |
brain | soma | Rattus norvegicus | - |
hippocampus | primary hippocampal neurons | Homo sapiens | - |
hippocampus | primary hippocampal neurons | Rattus norvegicus | - |
neuron | primary hippocampal neurons and immortalized GnRH neurons, i.e. GT1-7 cells | Homo sapiens | - |
neuron | primary hippocampal neurons and immortalized GnRH neurons, i.e. GT1-7 cells | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + tau peptide 408-420 | recombinant substrate expressed in Escherichia coli, phosphorylation at Ser416 by CaM kinase II, no activity with the peptide by CDK5, EC 2.7.11.22, and casein kinase II, EC 2.7.11.26 | Homo sapiens | ADP + phosphorylated tau peptide 408-420 | - |
? | |
ATP + tau peptide 408-420 | recombinant substrate expressed in Escherichia coli, phosphorylation at Ser416 by CaM kinase II, no activity with the peptide by CDK5, EC 2.7.11.22, and casein kinase II, EC 2.7.11.26 | Rattus norvegicus | ADP + phosphorylated tau peptide 408-420 | - |
? | |
ATP + tau protein | phosphorylation at Ser416 by CaM kinase II is high in early stages of brain development | Rattus norvegicus | ADP + phosphorylated tau protein | - |
? | |
ATP + tau protein | phosphorylation at Ser416 by CaM kinase II is high in early stages of brain development, CaM kinase II is involved in the accumulation of tau in neuronal soma in Alzheimer's disease brain | Homo sapiens | ADP + phosphorylated tau protein | - |
? | |
ATP + tau protein | recombinant substrate expressed in Escherichia coli, determination of phosphorylation sites, phosphorylation at Ser416 by CaM kinase II, tau is also a substrate for CDK5, EC 2.7.11.22, and casein kinase II, EC 2.7.11.26 | Homo sapiens | ADP + phosphorylated tau protein | - |
? | |
ATP + tau protein | recombinant substrate expressed in Escherichia coli, determination of phosphorylation sites, phosphorylation at Ser416 by CaM kinase II, tau is also a substrate for CDK5, EC 2.7.11.22, and casein kinase II, EC 2.7.11.26 | Rattus norvegicus | ADP + phosphorylated tau protein | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Ca2+/calmodulin-dependent protein kinase II | - |
Homo sapiens |
Ca2+/calmodulin-dependent protein kinase II | - |
Rattus norvegicus |
CaM kinase II | - |
Homo sapiens |
CaM kinase II | - |
Rattus norvegicus |
CaM kinase IIalpha | - |
Homo sapiens |
CaM kinase IIalpha | - |
Rattus norvegicus |
More | cf. EC 2.7.11.26 | Homo sapiens |
More | cf. EC 2.7.11.26 | Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Homo sapiens |
30 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |
7.5 | - |
assay at | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens | |
ATP | - |
Rattus norvegicus |