Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.11.17 extracted from

  • Song, T.; Hatano, N.; Horii, M.; Tokumitsu, H.; Yamaguchi, F.; Tokuda, M.; Watanabe, Y.
    Calcium/calmodulin-dependent protein kinase I inhibits neuronal nitric-oxide synthase activity through serine 741 phosphorylation (2004), FEBS Lett., 570, 133-137.
    View publication on PubMed
Search for more literature for 2.7.11.17

Activating Compound

Activating Compound Comment Organism Structure
Calmodulin dependent on Rattus norvegicus
additional information CaM-K Ialpha is activated in vitro by phosphorylation through kinase CaM-KK at Thr177 independently of Ca2+ and calmodulin Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
expression of HA-tagged wild-type CaM-KIalpha, CaM-K IV, and CaM-K IIalpha, and CaM-K Ialpha mutant K49A, and constitutively active CaM-K Ialpha truncation mutant residues 1-293 in HEK293 cells, Escherichia coli, and Sf9 insect cells Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ dependent on Rattus norvegicus
Mg2+
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + neuronal nitric-oxide synthase Rattus norvegicus phosphorylation at Ser741 by CaM-K Ialpha, wild-type and truncation mutant 1-293 inhibits neuronal nitric-oxide synthase, nNOS, no substrate of CaM-K IIalpha and CaM-K IV ADP + phosphorylated neuronal nitric-oxide synthase
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein CaM-K performs autophosphorylation, CaM-K Ialpha is activated in vitro by phosphorylation through kinase CaM-KK at Thr177 independently of Ca2+ and calmodulin Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + neuronal nitric-oxide synthase phosphorylation at Ser741 by CaM-K Ialpha, wild-type and truncation mutant 1-293 inhibits neuronal nitric-oxide synthase, nNOS, no substrate of CaM-K IIalpha and CaM-K IV Rattus norvegicus ADP + phosphorylated neuronal nitric-oxide synthase
-
 ?
ATP + neuronal nitric-oxide synthase phosphorylation at Ser741 by CaM-K Ialpha, wild-type and truncation mutant 1-293 inhibits neuronal nitric-oxide synthase, nNOS, no substrate of CaM-K IIalpha and CaM-K IV, determination of phosphorylation sites by analytical SDS-PAGE Rattus norvegicus ADP + phosphorylated neuronal nitric-oxide synthase
-
 ?

Synonyms

Synonyms Comment Organism
calcium/calmodulin-dependent protein kinase I
-
 Rattus norvegicus
calcium/calmodulin-dependent protein kinase II
-
 Rattus norvegicus
CaM-dependent protein kinase I
-
 Rattus norvegicus
CaM-dependent protein kinase II
-
 Rattus norvegicus
CaM-K Ialpha
-
 Rattus norvegicus
CaM-K IIalpha
-
 Rattus norvegicus
CaM-K IV
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus