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Literature summary for 2.7.11.17 extracted from
- Pseudosubstrate-based peptide inhibitors (1991), Methods Enzymol., 201, 287-304.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ARRKWQKTGHAVRAIGRLSS | calmodulin antagonist peptide, IC50: 33.3 nM in H2O, 10.6 nM in buffer containing 0.1% w/v Tween 80 | eukaryota |  |
| additional information | synthesis of peptides behaving as autoregulatory pseudosubstrates, determination of inhibitory potential, sequences of autoregulatory regions of the different enzyme forms, required sequence properties, overview | eukaryota |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | binding required for activity | eukaryota | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a protein | eukaryota | - |
ADP + a phosphoprotein | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| eukaryota | - |
enzyme forms alpha, beta, gamma, delta | - |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | autophosphorylation at Ser19 | eukaryota |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + a protein | - |
eukaryota | ADP + a phosphoprotein | - |
? | |
| additional information | substrate specificity | eukaryota | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Cam-II PK | - |
eukaryota |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
eukaryota | |
| Calmodulin | binding required for activity | eukaryota | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | Ki values of the pseudosubstrates in nano- to micromolar range | eukaryota |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0000333 | - |
calmodulin antagonist peptide, IC50: 33.3 nM in H2O, 10.6 nM in buffer containing 0.1% w/v Tween 80 | eukaryota | ARRKWQKTGHAVRAIGRLSS | |
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