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Literature summary for 2.7.11.16 extracted from
- S-nitrosylation of G protein-coupled receptor kinase 6 and casein kinase 2 alpha modulates their kinase activity toward alpha-synuclein phosphorylation in an animal model of Parkinsons disease (2020), PLoS ONE, 15, e0232019 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Mus musculus and HEK-293T cells | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + [alpha-synuclein] | Homo sapiens | the enzyme phosphorylates alpha-synuclein at Ser129 | ADP + [alpha-synuclein]phosphate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P43250 | - |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| nitrosylation | S-nitrosylation of isoform GRK6 by nitric oxide enhances the kinase activity towards the phosphorylation of alpha-synuclein | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + [alpha-synuclein] | the enzyme phosphorylates alpha-synuclein at Ser129 | Homo sapiens | ADP + [alpha-synuclein]phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| G protein-coupled receptor kinase 6 | - |
Homo sapiens |
| GRK6 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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