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Literature summary for 2.7.11.16 extracted from

  • Lagman, J.; Sayegh, P.; Lee, C.S.; Sulon, S.M.; Jacinto, A.Z.; Sok, V.; Peng, N.; Alp, D.; Benovic, J.L.; So, C.H.
    G protein-coupled receptor kinase 5 modifies cancer cell resistance to paclitaxel (2019), Mol. Cell. Biochem., 461, 103-118 .
    View publication on PubMed
Search for more literature for 2.7.11.16

Application

Application Comment Organism
medicine reducing enzyme protein expression in HeLa cells increases its sensitivity to paclitaxel and docetaxel and increases apoptosis in response to paclitaxel treatment Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [G-protein-coupled receptor] Homo sapiens
-
 ADP + [G-protein-coupled receptor] phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P34947
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
-
 Homo sapiens
-
cervical carcinoma cell
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
-
MDA-MB-231 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + histone deacetylase 6 the enzyme phosphorylates histone deacetylase 6 at Ser21 to promote its deacetylase activity Homo sapiens ADP + phosphorylated histone deacetylase 6
-
 ?
ATP + [G-protein-coupled receptor]
-
 Homo sapiens ADP + [G-protein-coupled receptor] phosphate
-
 ?

Subunits

Subunits Comment Organism
? x * 75000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
G protein-coupled receptor kinase 5
-
 Homo sapiens
GRK5
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function enzyme-histone deacetylase 6 interaction contributes to paclitaxel resistance in cancer cells Homo sapiens