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Literature summary for 2.7.11.16 extracted from

  • Yao, S.; Wu, D.; Chen, J.; Wang, P.; Lv, X.; Huang, J.
    Hypermethylation of the G protein-coupled receptor kinase 6 (GRK6) promoter inhibits binding of C/EBPalpha, and GRK6 knockdown promotes cell migration and invasion in lung adenocarcinoma cells (2019), FEBS Open Bio, 9, 605-617 .
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine low expression levels of isoform GRK6 are correlated with poor survival prognosis in patients with lung adenocarcinoma Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [G protein-coupled receptor] Homo sapiens
-
 ADP + [G protein-coupled receptor]phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P43250
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-427 cell
-
 Homo sapiens
-
A-549 cell
-
 Homo sapiens
-
lung adenocarcinoma cell
-
 Homo sapiens
-
NCI-H1299 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [G protein-coupled receptor]
-
 Homo sapiens ADP + [G protein-coupled receptor]phosphate
-
 ?

Synonyms

Synonyms Comment Organism
G protein-coupled receptor kinase 6
-
 Homo sapiens
GRK6
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens isoform GRK6 is significantly downregulated in lung adenocarcinoma tissues. Inhibition of CCAAT/enhancer-binding protein-alpha significantly inhibits isoform GRK6 expression down
Homo sapiens treatment with 5-aza-2'-deoxycytidine significantly enhances isoform GRK6 gene expression. Overexpression of C/EBPalpha significantly promotes isoform GRK6 expression up

General Information

General Information Comment Organism
malfunction isoform GRK6 knockdown promotes cell migration and invasion in lung adenocarcinoma cells Homo sapiens
physiological function isoform GRK6 regulates epithelial-mesenchymal transition phenotypes and matrix metalloproteinase expression. Hypermethylation of the GRK6 gene promoter suppresses binding of CCAAT/enhancer-binding protein-alpha, thereby contributing to the promotion of cell migration and invasion in lung adenocarcinoma Homo sapiens