Literature summary for 2.7.11.16 extracted from

Bychkov, E.; Zurkovsky, L.; Garret, M.B.; Ahmed, M.R.; Gurevich, E.V.
Distinct cellular and subcellular distributions of G protein-coupled receptor kinase and arrestin isoforms in the striatum (2012), PLoS ONE, 7, e48912.

Search for more literature for 2.7.11.16

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	-	Rattus norvegicus	5737	-
cytoplasm	the GRK5 subcellular distribution in the human striatal neurons is altered by its phosphorylation: phosphorylated GRK5 is found in plasma membrane and cytosolic fractions	Rattus norvegicus	5737	-
membrane	the GRK5 subcellular distribution in the human striatal neurons is altered by its phosphorylation: unphosphorylated enzyme preferentially localizes to synaptic membranes	Rattus norvegicus	16020	-
nucleus	GRK2 is enriched more than 4fold in the nucleus compared to cytoplasm	Rattus norvegicus	5634	-
nucleus	phosphorylated GRK5 is enriched more than 4fold in the nucleus compared to cytoplasm	Rattus norvegicus	5634	-
plasma membrane	the GRK5 subcellular distribution in the human striatal neurons is altered by its phosphorylation: phosphorylated GRK5 is found in plasma membrane and cytosolic fractions	Rattus norvegicus	5886	-

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	the GRK5 subcellular distribution in the human striatal neurons is altered by its phosphorylation	Rattus norvegicus

Source Tissue

Source Tissue	Comment	Organism	Textmining
cholinergic neuron	enriched in GRK2 and GRK5	Rattus norvegicus	-
neuron	parvalbumin-positive interneurons express more of GRK2 and less of arrestin-2 than medium spiny	Rattus norvegicus	-
striatum	-	Rattus norvegicus	-

Synonyms

Synonyms	Comment	Organism
GRK2	-	Rattus norvegicus
GRK5	-	Rattus norvegicus

Expression

Organism	Comment	Expression
Rattus norvegicus	parvalbumin-positive interneurons express more of GRK2 and less of arrestin-2 than medium spiny neurons	up

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Release 2023.1 (January 2023)