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Literature summary for 2.7.11.16 extracted from

  • Guo, Q.; Subramanian, H.; Gupta, K.; Ali, H.
    Regulation of C3a receptor signaling in human mast cells by G protein coupled receptor kinases (2011), PLoS ONE, 6, e22559.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.16

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
HMC-1 cell
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
GRK2
-
 Homo sapiens
GRK3
-
 Homo sapiens
GRK5
-
 Homo sapiens
GRK6
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction GRK5 or GRK6 knockdown has no effect on C3aR (G protein coupled receptors for C3a) desensitization, but causes a significant decrease in C3a-induced mast cell degranulation. GRK5 or GRK6 knockdown render mast cells more responsive to C3a for ERK1/2 phosphorylation Homo sapiens
malfunction knockdown of GRK2 or GRK3 expression using shRNA causes a more sustained Ca2+ mobilization, attenuated C3aR (G protein coupled receptors for C3a) desensitization, and enhanced degranulation as well as ERK1/2 phosphorylation when compared to shRNA control cells Homo sapiens
physiological function GRK2 and GRK3 are involved in C3aR (G protein coupled receptors for C3a) desensitization Homo sapiens
physiological function GRK5 and GRK6 promote C3a-induced mast cell degranulation but inhibit ERK1/2 phosphorylation via C3aR desensitization-independent mechanisms Homo sapiens