Literature summary for 2.7.11.16 extracted from

Kim, J.I.; Chakraborty, P.; Wang, Z.; Daaka, Y.
G-protein coupled receptor kinase 5 regulates prostate tumor growth (2012), J. Urol., 187, 322-329.

Search for more literature for 2.7.11.16

Protein Variants

Protein Variants	Comment	Organism
K215R	inactive kinase mutant is not able to rescue the phenotype of PC3 cells that stably express lentiviral small hairpin RNA and target GRK5. Over expression of kinase-inactive K215R, GRK5, or GRK5 knockdown leads to G2/M arrest in the cell cycle	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
PC-3 cell	highly expressed	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
GRK5	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	over expression of kinase-inactive K215R GRK5 or GRK5 knockdown leads to G2/M arrest in the cell cycle. Loss of GRK5 activity results in decreased cyclin D1 expression, Rb protein phosphorylation and E2F target gene expression involved in cell cycle control	Homo sapiens
malfunction	silencing of GRK5 by RNA interference attenuates in vitro cell proliferation. Reduced expression of GRK5 goes ahead with reduced xenograft tumor growth in mice	Homo sapiens
physiological function	GRK5 has an important role in the regulation of prostate tumor growth	Homo sapiens

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Release 2023.1 (January 2023)