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Literature summary for 2.7.11.16 extracted from

  • Wang, L.; Gesty-Palmer, D.; Fields, T.A.; Spurney, R.F.
    Inhibition of WNT signaling by G protein-coupled receptor (GPCR) kinase 2 (GRK2) (2009), Mol. Endocrinol., 23, 1455-1465.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine inhibition of GRK2 activity in osteoblasts as therapeutic strategy for increasing bone mass Homo sapiens

Protein Variants

Protein Variants Comment Organism
K220R kinase-dead mutant Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + ATP + G protein-coupled receptor Homo sapiens
-
ADP + phosphorylated G protein-coupled receptor
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + ATP + G protein-coupled receptor
-
Homo sapiens ADP + phosphorylated G protein-coupled receptor
-
?

Synonyms

Synonyms Comment Organism
G protein-coupled receptor kinase 2
-
Homo sapiens
GPCR kinase 2
-
Homo sapiens
GRK2
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens

General Information

General Information Comment Organism
malfunction depletion of endogenous GRK2 enhances canonical signaling Homo sapiens
physiological function GRK2 inhibits Wnt1-induced activation of a reporter construct and reduces Wnt3a-dependent stabilization and nuclear translocation of beta-catenin, Homo sapiens