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Literature summary for 2.7.11.16 extracted from

  • Martini, J.S.; Raake, P.; Vinge, L.E.; DeGeorge, B.; Chuprun, J.K.; Harris, D.M.; Gao, E.; Eckhart, A.D.; Pitcher, J.A.; Koch, W.J.
    Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes (2008), Proc. Natl. Acad. Sci. USA, 105, 12457-12462.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
co-overexpression of GRK5 with MEF2 receptor leads to increased MEF2 activity in myocytes Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information cardiac GRK5 overexpression augments hypertrophy in vivo, pressure overload causes GRK5 nuclear accumulation in vivo, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information chronic Gq signaling results in the translocation of GRK5 to the nucleus, where GRK5 activity plays a role in MEF2 activation, which has implications for induction of hypertrophic gene expression Mus musculus
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nucleus
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Mus musculus 5634
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus GRK5 is important for myocardial regulation, and is up-regulated in the dysfunctional heart. But GRK5 also is a nuclear a class II histone deacetylase kinase that plays a key role in maladaptive cardiac hypertrophy apparently independent of any action directly on G protein coupled receptors, overview. Chronic Gq signaling results in the translocation of GRK5 to the nucleus, where GRK5 activity plays a role in MEF2 activation, which has implications for induction of hypertrophic gene expression. GRK5 interacts with histone deacetylase kinases in vivo ?
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?

Organism

Organism UniProt Comment Textmining
Mus musculus Q8VEB1
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Source Tissue

Source Tissue Comment Organism Textmining
cardiomyocyte
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Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + alpha1-adrenergic receptor GRK5 is also active with alpha1-adrenergic receptors. GRK5 activity, but not GRK2 activity, toward alpha1-adrenergic receptors can lead to transactivation of the tyrosine kinase receptor for epidermal growth factor in myocytes, cf. EC 2.7.11.15 Mus musculus ADP + alpha1-adrenergic receptor phosphate
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?
additional information GRK5 is important for myocardial regulation, and is up-regulated in the dysfunctional heart. But GRK5 also is a nuclear a class II histone deacetylase kinase that plays a key role in maladaptive cardiac hypertrophy apparently independent of any action directly on G protein coupled receptors, overview. Chronic Gq signaling results in the translocation of GRK5 to the nucleus, where GRK5 activity plays a role in MEF2 activation, which has implications for induction of hypertrophic gene expression. GRK5 interacts with histone deacetylase kinases in vivo Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
GRK5
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Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
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Mus musculus