Cloned (Comment) | Organism |
---|---|
co-overexpression of GRK5 with MEF2 receptor leads to increased MEF2 activity in myocytes | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | cardiac GRK5 overexpression augments hypertrophy in vivo, pressure overload causes GRK5 nuclear accumulation in vivo, overview | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
additional information | chronic Gq signaling results in the translocation of GRK5 to the nucleus, where GRK5 activity plays a role in MEF2 activation, which has implications for induction of hypertrophic gene expression | Mus musculus | - |
- |
nucleus | - |
Mus musculus | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | GRK5 is important for myocardial regulation, and is up-regulated in the dysfunctional heart. But GRK5 also is a nuclear a class II histone deacetylase kinase that plays a key role in maladaptive cardiac hypertrophy apparently independent of any action directly on G protein coupled receptors, overview. Chronic Gq signaling results in the translocation of GRK5 to the nucleus, where GRK5 activity plays a role in MEF2 activation, which has implications for induction of hypertrophic gene expression. GRK5 interacts with histone deacetylase kinases in vivo | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q8VEB1 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cardiomyocyte | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + alpha1-adrenergic receptor | GRK5 is also active with alpha1-adrenergic receptors. GRK5 activity, but not GRK2 activity, toward alpha1-adrenergic receptors can lead to transactivation of the tyrosine kinase receptor for epidermal growth factor in myocytes, cf. EC 2.7.11.15 | Mus musculus | ADP + alpha1-adrenergic receptor phosphate | - |
? | |
additional information | GRK5 is important for myocardial regulation, and is up-regulated in the dysfunctional heart. But GRK5 also is a nuclear a class II histone deacetylase kinase that plays a key role in maladaptive cardiac hypertrophy apparently independent of any action directly on G protein coupled receptors, overview. Chronic Gq signaling results in the translocation of GRK5 to the nucleus, where GRK5 activity plays a role in MEF2 activation, which has implications for induction of hypertrophic gene expression. GRK5 interacts with histone deacetylase kinases in vivo | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GRK5 | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |