Literature summary for 2.7.11.16 extracted from

Fraga, S.; Luo, Y.; Jose, P.; Zandi-Nejad, K.; Mount, D.B.; Soares-da-Silva, P.
Dopamine D1-like receptor-mediated inhibition of Cl/HCO3- exchanger activity in rat intestinal epithelial IEC-6 cells is regulated by G protein-coupled receptor kinase 6 (GRK 6) (2006), Cell. Physiol. Biochem., 18, 347-360.

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Inhibitors

Inhibitors	Comment	Organism	Structure
heparin	inhibits GRK6	Rattus norvegicus

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	-	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + dopamine D1 receptor	Rattus norvegicus	dopamine D1 receptors in IEC-6 rapidly desensitize to D1-like agonist stimulation and GRK 6 isozymes A and B, but not GRK 4, appear to be involved in agonist-mediated responsiveness and desensitization	ADP + phosphorylated dopamine D1 receptor	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	isozyme GRK6 A and GRK6 B	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
crypt	-	Rattus norvegicus	-
IEC-6 cell	intestinal epithelial cell line	Rattus norvegicus	-
villus	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + dopamine D1 receptor	-	Rattus norvegicus	ADP + phosphorylated dopamine D1 receptor	-	?
ATP + dopamine D1 receptor	dopamine D1 receptors in IEC-6 rapidly desensitize to D1-like agonist stimulation and GRK 6 isozymes A and B, but not GRK 4, appear to be involved in agonist-mediated responsiveness and desensitization	Rattus norvegicus	ADP + phosphorylated dopamine D1 receptor	-	?

Synonyms

Synonyms	Comment	Organism
by G protein-coupled receptor kinase 6	-	Rattus norvegicus
GRK6	-	Rattus norvegicus

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Rattus norvegicus

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Release 2023.1 (January 2023)