Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | phosphorylation activates the enzyme | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
actin | - |
Homo sapiens | |
alpha-actinin | - |
Homo sapiens | |
Calmodulin | - |
Homo sapiens | |
caveolin | - |
Homo sapiens | |
RKIP | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Mammalia | 16020 | - |
nucleus | GRK5 | Mammalia | 5634 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
69000 | - |
x * 69000, GRK5, SDS-PAGE | Homo sapiens |
69000 | - |
x * 69000, about, GRK5 catalytic domain, domain structure, overview | Mammalia |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | GRK activity is regulated by phosphorylation through several kinases and by interactions with several cellular proteins, e.g. calmodulin, caveolin or RKIP, GRK also interacts with PI3K, Akt, GIT or MEK, the interactions occur at the RH and PH domains, overview, the GRK interactome: role of GRKs in GPCR regulation and signaling, detailed overview | ? | - |
? | |
additional information | Mammalia | G protein-coupled receptor kinases and arrestins are key participants in the canonical pathways leading to phosphorylation-dependent G protein-coupled receptor, GPCR, desensitization, endocytosis, intracellular trafficking and resensitization as well as in the modulation of important intracellular signaling cascades by GPCR, structure-function relationships, overview. GRK activity is tightly modulated by mechanisms including phosphorylation by different kinases and interaction with several cellular proteins such as calmodulin, caveolin or RKIP | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mammalia | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | phosphorylation, e.g. by PKA, PKC, ERK1/2 or c-SRC, activates the enzyme | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cerebellum | GRK4 | Mammalia | - |
kidney | GRK4 | Mammalia | - |
additional information | GRK5 and GRK6 are ubiquitously expressed in mammalian tissues | Mammalia | - |
testis | GRK4 | Mammalia | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | GRK activity is regulated by phosphorylation through several kinases and by interactions with several cellular proteins, e.g. calmodulin, caveolin or RKIP, GRK also interacts with PI3K, Akt, GIT or MEK, the interactions occur at the RH and PH domains, overview, the GRK interactome: role of GRKs in GPCR regulation and signaling, detailed overview | Homo sapiens | ? | - |
? | |
additional information | G protein-coupled receptor kinases and arrestins are key participants in the canonical pathways leading to phosphorylation-dependent G protein-coupled receptor, GPCR, desensitization, endocytosis, intracellular trafficking and resensitization as well as in the modulation of important intracellular signaling cascades by GPCR, structure-function relationships, overview. GRK activity is tightly modulated by mechanisms including phosphorylation by different kinases and interaction with several cellular proteins such as calmodulin, caveolin or RKIP | Mammalia | ? | - |
? | |
additional information | no interaction of the RH domains of GRK5 and GRK6 with Galpha proteins. GRK5 contains a DNA-binding nuclear localization sequence that allows its binding to DNA and its localization in the nucleus upon GPCR activation, interaction with other oroteins, detailed overview | Mammalia | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 69000, GRK5, SDS-PAGE | Homo sapiens |
? | x * 69000, about, GRK5 catalytic domain, domain structure, overview | Mammalia |
More | domain structure of GRK4-6, overview | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
G protein-coupled receptor kinase 5 | - |
Homo sapiens |
GRK4 | - |
Mammalia |
GRK4 | - |
Homo sapiens |
GRK5 | - |
Mammalia |
GRK5 | - |
Homo sapiens |
GRK6 | - |
Mammalia |
GRK6 | - |
Homo sapiens |
More | the enzyme belongs to the GRK4 subfamily | Mammalia |
More | the enzyme belongs to the GRK4 subfamily | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |