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Literature summary for 2.7.11.16 extracted from

  • Penela, P.; Ribas, C.; Mayor, F.
    Mechanisms of regulation of the expression and function of G protein-coupled receptor kinases (2003), Cell. Signal., 15, 973-981.
    View publication on PubMed
Search for more literature for 2.7.11.16

Activating Compound

Activating Compound Comment Organism Structure
phosphatidylinositol 4,5-bisphosphate activates the receptor phosphorylation activity of GRK5, but not its autophosphorylation or peptide phosphorylation activity Mus musculus
phosphatidylinositol 4,5-bisphosphate activates the receptor phosphorylation activity of GRK5, but not its autophosphorylation or peptide phosphorylation activity Homo sapiens
Phospholipids activate GRK5 Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information construction of transgenic tissue specific or knockout mice Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
actinin inhibits GRK5 Homo sapiens
actinin inhibits GRK5 Mus musculus
Ca2+ inhibits GRK5 Mus musculus
Calmodulin inhibits GRK5 Homo sapiens
Calmodulin inhibits GRK5 Mus musculus
caveolin inhibits GRK5 Homo sapiens
caveolin inhibits GRK5 Mus musculus
additional information phosphorylation by PKC inhibits GRK5 Homo sapiens
additional information phosphorylation by PKC inhibits GRK5 Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ inhibits GRK5 Mus musculus
Ca2+ inhibits GRK5 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + G protein-coupled receptor Mus musculus regulation mechanism of GRK5, overview, regulation by phosphorylation at specific sites via distinct specific kinases, overview ADP + phosphorylated G protein-coupled receptor
-
 ?
ATP + G protein-coupled receptor Homo sapiens regulation mechanism of GRK5, overview, regulation by phosphorylation at specific sites via distinct specific kinases, overview ADP + phosphorylated G protein-coupled receptor
-
 ?
additional information Mus musculus GRKs are involved in diverse physiological processes and pathologies, overview ?
-
 ?
additional information Homo sapiens GRKs are involved in diverse physiological processes and pathologies, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
additional information mechanisms of regulation of GRK protein stability and degradation, e.g. via ubiquitination or protease cleavage, overview Mus musculus
additional information mechanisms of regulation of GRK protein stability and degradation, e.g. via ubiquitination or protease cleavage, overview Homo sapiens
phosphoprotein GRK5 performs autophosphorylation and is phosphorylated by protein kinase C Mus musculus
phosphoprotein GRK5 performs autophosphorylation and is phosphorylated by protein kinase C Homo sapiens

Reaction

Reaction Comment Organism Reaction ID
ATP + [G protein-coupled receptor] = ADP + [G protein-coupled receptor]phosphate regulation mechanism Mus musculus
a
ATP + [G protein-coupled receptor] = ADP + [G protein-coupled receptor]phosphate regulation mechanism Homo sapiens
a

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Mus musculus
-
heart
-
 Homo sapiens
-
additional information GRK5 and GRK6 are expressed in a wide variety of tissues, expression patterns, overview Mus musculus
-
additional information GRK5 and GRK6 are expressed in a wide variety of tissues, expression patterns, overview Homo sapiens
-
myelomonocytic leukemia cell GRK6 Mus musculus
-
myelomonocytic leukemia cell GRK6 Homo sapiens
-
T-lymphocyte
-
 Mus musculus
-
T-lymphocyte
-
 Homo sapiens
-
testis GRK4, mainly Mus musculus
-
testis GRK4, mainly Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + G protein-coupled receptor
-
 Mus musculus ADP + phosphorylated G protein-coupled receptor
-
 ?
ATP + G protein-coupled receptor
-
 Homo sapiens ADP + phosphorylated G protein-coupled receptor
-
 ?
ATP + G protein-coupled receptor regulation mechanism of GRK5, overview, regulation by phosphorylation at specific sites via distinct specific kinases, overview Mus musculus ADP + phosphorylated G protein-coupled receptor
-
 ?
ATP + G protein-coupled receptor regulation mechanism of GRK5, overview, regulation by phosphorylation at specific sites via distinct specific kinases, overview Homo sapiens ADP + phosphorylated G protein-coupled receptor
-
 ?
additional information GRKs are involved in diverse physiological processes and pathologies, overview Mus musculus ?
-
 ?
additional information GRKs are involved in diverse physiological processes and pathologies, overview Homo sapiens ?
-
 ?
additional information GRK5 performs autophosphorylation Mus musculus ?
-
 ?
additional information GRK5 performs autophosphorylation Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
More GRK4 subfamily multidomain structure, overview Mus musculus
More GRK4 subfamily multidomain structure, overview Homo sapiens

Synonyms

Synonyms Comment Organism
G protein-coupled receptor kinase
-
 Mus musculus
G protein-coupled receptor kinase
-
 Homo sapiens
GRK4
-
 Mus musculus
GRK4
-
 Homo sapiens
GRK5
-
 Mus musculus
GRK5
-
 Homo sapiens
GRK6
-
 Mus musculus
GRK6
-
 Homo sapiens
More enzymes belong to the GRK family, GRK4, GRK5, and GRK6 form the GRK4 subfamily Mus musculus
More enzymes belong to the GRK family, GRK4, GRK5, and GRK6 form the GRK4 subfamily Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus
ATP
-
 Homo sapiens