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Literature summary for 2.7.11.16 extracted from

  • Walker, J.K.; Gainetdinov, R.R.; Feldman, D.S.; McFawn, P.K.; Caron, M.G.; Lefkowitz, R.J.; Premont, R.T.; Fisher, J.T.
    G protein-coupled receptor kinase 5 regulates airway responses induced by muscarinic receptor activation (2004), Am. J. Physiol., 286, L312-319.
    View publication on PubMed
Search for more literature for 2.7.11.16

Protein Variants

Protein Variants Comment Organism
additional information construction of GRK5 deletion mutant mice Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + central M2 muscarinic receptor Mus musculus desensitization of the receptor by GRK5, GRK5 regulates pulmmonary responses by activation of the airway receptor, but does not regulate the peripheral cardiac muscarinic receptors ADP + phosphorylated central M2 muscarinic receptor
-
 ?
additional information Mus musculus GRK5 defects can cause obstructive airway diseases such as asthma ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lung GRK5 Mus musculus
-
smooth muscle airway, GRK5 Mus musculus
-
trachea GRK5 Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 physiologic activity of lungs in wild-type and GRK5-deficient mice, overview Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + central M2 muscarinic receptor desensitization of the receptor by GRK5, GRK5 regulates pulmmonary responses by activation of the airway receptor, but does not regulate the peripheral cardiac muscarinic receptors Mus musculus ADP + phosphorylated central M2 muscarinic receptor
-
 ?
ATP + central M2 muscarinic receptor GRK5 Mus musculus ADP + phosphorylated central M2 muscarinic receptor
-
 ?
additional information GRK5 defects can cause obstructive airway diseases such as asthma Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
G protein-coupled receptor kinase 5
-
 Mus musculus
GPCR kinase
-
 Mus musculus
GRK5
-
 Mus musculus
More GRK5 is a member of the GRK family Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus