Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | GRK5 protein does not undergo agonist-dependent translocation from cytosol to membranes as do beta-adrenergic receptor kinase and rhodopsin kinase, but rather appears to associate with membranes constitutively | Bos taurus | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | P43249 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | major autophosphorylation sites are Ser484 and Thr485 | Bos taurus |
Purification (Comment) | Organism |
---|---|
- |
Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | very weak activity | Bos taurus | - |
heart | high activity | Bos taurus | - |
kidney | very weak activity | Bos taurus | - |
liver | very weak activity | Bos taurus | - |
lung | high activity | Bos taurus | - |
additional information | most abundantly in lung, heart, retina, and lingual epithelium, but expressed very little in brain, liver, kidney, or testis | Bos taurus | - |
retina | high activity | Bos taurus | - |
testis | very weak activity | Bos taurus | - |
tongue epithelium | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + beta 2-adrenergic receptor | phosphorylation in an agonist-dependent manner, phosphorylates the C-terminal tail regions of both receptor proteins | Bos taurus | ADP + phosphorylated beta 2-adrenergic receptor | - |
? | |
ATP + protein | major autophosphorylation sites are Ser484 and Thr485 | Bos taurus | ADP + phosphoprotein | - |
? | |
ATP + rhodopsin | GRK5 phosphorylates rhodopsin in a light-dependent manner, phosphorylates the C-terminal tail region | Bos taurus | ADP + phosphorylated rhodopsin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
G protein-coupled receptor kinase GRK5 | - |
Bos taurus |
GRK5 | - |
Bos taurus |