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Literature summary for 2.7.11.15 extracted from
- Role of G protein-coupled receptor kinase 2 in tumoral angiogenesis (2016), Mol. Cell. Oncol., 1, e969166.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + [beta-adrenergic receptor] | Mus musculus | - |
ADP + phospho-[beta-adrenergic receptor] | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| endothelial cell | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + [beta-adrenergic receptor] | - |
Mus musculus | ADP + phospho-[beta-adrenergic receptor] | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| G protein-coupled receptor kinase 2 | - |
Mus musculus |
| GRK2 | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | decreased enzyme expression in endothelial cells accelerates tumor growth in mice by impairing the pericytes ensheathing the vessels, thereby promoting hypoxia and macrophage infiltration | Mus musculus |
| physiological function | the enzyme regulates physiological and tumor vascularization | Mus musculus |
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Release 2023.1 (January 2023)
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