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Literature summary for 2.7.11.15 extracted from

  • Robinson, J.D.; Pitcher, J.A.
    G protein-coupled receptor kinase 2 (GRK2) is a Rho-activated scaffold protein for the ERK MAP kinase cascade (2013), Cell. Signal., 25, 2831-2839.
    View publication on PubMed
Search for more literature for 2.7.11.15

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [beta-adrenergic receptor] Rattus norvegicus
-
 ADP + phospho-[beta-adrenergic receptor]
-
 ?
additional information Rattus norvegicus RhoAGTP is a binding partner for enzyme GRK2 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
vascular smooth muscle cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [beta-adrenergic receptor]
-
 Rattus norvegicus ADP + phospho-[beta-adrenergic receptor]
-
 ?
additional information RhoAGTP is a binding partner for enzyme GRK2 Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
G protein-coupled receptor kinase 2
-
 Rattus norvegicus
GRK2
-
 Rattus norvegicus

General Information

General Information Comment Organism
metabolism G protein-coupled receptor kinase 2 is a RhoA effector that serves as a RhoA-activated scaffold protein for the ERK MAP kinase cascade Rattus norvegicus
physiological function the enzyme is required for epidermal growth factor-induced, Rho- and ERK-dependent thymidine incorporation in vascular smooth muscle cells. Increased levels of GRK2 are associated with hypertension Rattus norvegicus